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Outlook of various diagnostics and nanodiagnostic techniques for COVID-19
Mosam Preethi1, Lavanika Roy1, Sukanya Lahkar1
1NanoBioSens Lab, Department of Medical Devices, National Institute of Pharmaceutical Education & Research (NIPER) Hyderabad, Hyderabad, 500037, Telangana, India.
Insights
Nanodiagnostic devices offer faster, easier COVID-19 diagnosis than traditional methods. These nanotechnology-based tools show promise for point-of-care testing and personalized healthcare.
Area of Science:
- Biomedical Engineering
- Nanotechnology
- Infectious Disease Diagnostics
Background:
- The COVID-19 pandemic highlighted global health vulnerabilities and the need for rapid diagnostic solutions.
- Conventional methods like RT-PCR face challenges in speed and accessibility.
- Nanodiagnostic devices, utilizing nanomaterials, offer innovative alternatives.
Purpose of the Study:
- To review current COVID-19 diagnostic techniques.
- To emphasize the role and advantages of nanotechnology-based diagnostic devices.
- To discuss the potential of nanodiagnostics in clinical and point-of-care settings.
Main Methods:
- Review of existing literature on COVID-19 diagnostics.
- Focus on nanotechnology-based biosensing platforms (nanoparticles, nanotubes, nanowires).
- Analysis of commercialized and developmental nanodiagnostic devices.
Main Results:
- Nanodiagnostic devices provide advantages over RT-PCR, including speed, ease of use, and miniaturization.
- These devices are suitable for point-of-care (POC) applications.
- Current research and development show significant progress in nanodiagnostic device commercialization.
Conclusions:
- Nanodiagnostic devices represent a significant advancement in infectious disease diagnostics.
- Their potential for rapid, accessible testing can improve public health responses.
- Future applications include enhanced clinical diagnostics and personalized healthcare strategies.
Abstract:
The sudden outbreak of the coronavirus disease 2019 (COVID-19) pandemic has brought to the fore the existing threat of disease-causing pathogens that affect public health all over the world. It has left the best healthcare systems struggling to contain the spread of disease and its consequences. Under challenging circumstances, several innovative technologies have emerged that facilitated quicker diagnosis and treatment. Nanodiagnostic devices are biosensing platforms developed using nanomaterials such as nanoparticles, nanotubes, nanowires, etc. These devices have the edge over conventional techniques such as reverse transcription-polymerase chain reaction (RT-PCR) because of their ease of use, quicker analysis, possible miniaturization, and scope for use in point-of-care (POC) treatment. This review discusses the techniques currently used for COVID-19 diagnosis, emphasizing nanotechnology-based diagnostic devices. The commercialized nanodiagnostic devices in various research and development stages are also reviewed. The advantages of nanodiagnostic devices over other techniques are discussed, along with their limitations. Additionally, the important implications of the utility of nanodiagnostic devices in COVID-19, their prospects for future development for use in clinical and POC settings, and personalized healthcare are also discussed.
