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Highly resilient porous polyurethane composite scaffolds filled with whitlockite for bone tissue engineering
Jingjing Du1, Yang Zhang2, Jiaqi Wang2
1Analytical & Testing Center, Hainan University, Haikou, P.R. China.
Journal of Biomaterials Science. Polymer Edition
|November 8, 2022
Summary
New whitlockite/polyurethane (WH/PU) composite scaffolds show promise for bone tissue engineering. These WH/PU scaffolds exhibit excellent mechanical properties, high porosity, and promote cell growth, suggesting suitability for bone regeneration applications.
Area of Science:
- Biomaterials Science
- Materials Chemistry
- Tissue Engineering
Background:
- Developing advanced composite scaffolds is crucial for bone tissue engineering.
- Whitlockite (WH) and polyurethane (PU) are promising materials for bone regeneration applications.
Purpose of the Study:
- To synthesize and characterize whitlockite/polyurethane (WH/PU) composite scaffolds.
- To evaluate the physical, mechanical, and biological properties of WH/PU scaffolds for bone tissue engineering.
Main Methods:
- WH/PU composite scaffolds were synthesized via in situ polymerization.
- Characterization included FTIR, XRD, SEM, EDS, porosity measurement, contact angle, and mechanical compression tests.
- Cytocompatibility was assessed using MC3T3-E1 cells.
Main Results:
- WH and PU were well-integrated in the composite scaffolds.
- WH/PU scaffolds demonstrated a maximum compressive strength of 5.2 MPa and elastic modulus of 14.1 MPa.
- Scaffolds exhibited up to 73% porosity, good elasticity, shape recovery, and enhanced MC3T3-E1 cell proliferation and activity.
Conclusions:
- WH/PU composite scaffolds possess favorable mechanical and physical properties.
- The scaffolds show excellent cytocompatibility and promote osteogenic activity.
- WH/PU composite scaffolds are a promising candidate for bone tissue engineering applications.
