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An NO-responsive probe for detecting acute inflammation using NIR-II fluorescence/optoacoustic imaging
Zunpan She1, Junjie Chen1, Lihe Sun1
1State Key Laboratory of Luminescent Materials and Devices, Guangdong Provincial Key Laboratory of Luminescence from Molecular Aggregates, College of Materials Science and Engineering, South China University of Technology, Guangzhou 510640, China. mcfzeng@scut.edu.cn.
Chemical Communications (Cambridge, England)
|November 8, 2022
Summary
A new probe detects nitric oxide (NO) in acute inflammation, providing clear imaging signals. This tool aids in visualizing inflammatory conditions like dermatitis and joint inflammation.
Area of Science:
- Biomedical imaging
- Molecular imaging
- Inflammation research
Background:
- Acute inflammation is a critical condition requiring accurate diagnostic tools.
- Nitric oxide (NO) plays a key role in inflammatory processes.
- Current imaging methods for acute inflammation have limitations.
Purpose of the Study:
- To develop and validate a novel NO-responsive probe for enhanced imaging of acute inflammation.
- To assess the probe's efficacy in preclinical models of inflammation.
Main Methods:
- Synthesis and characterization of a NO-responsive fluorescent probe.
- Evaluation of probe response to nitric oxide (NO).
- In vivo imaging of LPS-induced dermatitis and MIA-induced joint inflammation models using the probe.
Main Results:
- The developed probe exhibits a 'turn-on' fluorescence response to endogenous NO.
- High sensitivity and specificity for NO in inflammatory microenvironments were observed.
- Clear visualization of acute inflammation sites was achieved using NIR-II fluorescence and optoacoustic imaging.
Conclusions:
- The NO-responsive probe is effective for non-invasive imaging of acute inflammation.
- This technology offers a promising tool for diagnosing and monitoring inflammatory diseases.
- The probe's dual-modal imaging capability (fluorescence and optoacoustic) enhances diagnostic accuracy.
