Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cognitive Enhancers: Cholinesterase Inhibitors and NMDA Receptor Antagonists01:30

Cognitive Enhancers: Cholinesterase Inhibitors and NMDA Receptor Antagonists

189
Cognitive enhancers, also known as "smart drugs," are substances used to enhance memory, mental alertness, and concentration. These can be natural or synthetic and improve cognition in conditions like Alzheimer's disease (AD) and other neurodegenerative diseases. Some common examples include caffeine, amphetamines, methylphenidate, modafinil, arecoline, donepezil, vortioxetine, and piracetam. These enhancers work on the principle of synaptic plasticity and altered circuit function.
189
Ligand-Gated Ion Channel Receptor: Gating Mechanism01:30

Ligand-Gated Ion Channel Receptor: Gating Mechanism

2.4K
Ligand-gated ion channels are transmembrane proteins that play a vital role in intercellular communication and functions of the nervous system. They allow the influx of ions across the membrane once the neurotransmitter binds, allowing the subsequent transmission of electrical excitation across the neurons. Other ligand-gated ion channels, like the γ-aminobutyric acid (GABA) receptor, permit anions like chloride into the cells on the binding of the GABA molecule. Their entry into the cell...
2.4K
Role of Neurotransmitters in Memory01:23

Role of Neurotransmitters in Memory

756
Neurotransmitters are integral to the brain's communication system, enabling neurons to transmit signals across synapses. This chemical exchange underpins various cognitive functions, including memory processes. The role of neurotransmitters in memory is multifaceted, influencing the encoding, consolidation, and retrieval of memories through their action on different neural circuits.
 Glutamate and Synaptic Plasticity
Glutamate, the brain's main excitatory neurotransmitter, is...
756
Neuroplasticity01:01

Neuroplasticity

687
Neuroplasticity reflects the brain's remarkable capacity to adapt and evolve, responding dynamically to learning, experiences, or injury by reorganizing its neural circuitry. This reorganization involves creating new neural connections and refining old ones through a series of biological processes that contribute to the brain's lifelong development and adaptability.
687
Alzheimer's Disease: Treatment01:22

Alzheimer's Disease: Treatment

245
Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
245
Drugs Affecting Neurotransmitter Synthesis01:29

Drugs Affecting Neurotransmitter Synthesis

1.5K
Drugs affecting neurotransmitter synthesis can impact the adrenergic neuron and the synthesis of neurotransmitters. For example, α-methyltyrosine and carbidopa target specific enzymes involved in catecholamine synthesis. α-methyltyrosine inhibits the enzyme tyrosine hydroxylase, which converts tyrosine into dopamine. By blocking this enzyme, α-methyltyrosine reduces dopamine production and other catecholamines. Carbidopa, on the other hand, inhibits the enzyme dopa decarboxylase,...
1.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Correction: Adeluola et al. Chemoprevention of 4-NQO-Induced Oral Cancer by the Combination of Resveratrol and EGCG: In Vivo, In Silico and In Vitro Studies. <i>Cancers</i> 2026, <i>18</i>, 1098.

Cancers·2026
Same author

Correction: Higher education students' perceptions of ChatGPT: A global study of early reactions.

PloS one·2026
Same author

Chemoprevention of 4-NQO-Induced Oral Cancer by the Combination of Resveratrol and EGCG: In Vivo, In Silico and In Vitro Studies.

Cancers·2026
Same author

Understanding complaint behavior in mobile banking: A psychological and AI-based analysis of emotional drivers.

Acta psychologica·2026
Same author

Insights and implications of a dynamical systems approach to dengue transmission and epidemic behaviour.

Scientific reports·2026
Same author

Effects of a 30-min rest with a nap chair on task performance, sleepiness, and neurophysiological measures in men with suspected brain fatigue: a randomized controlled crossover trial.

Frontiers in sleep·2025

Related Experiment Video

Updated: Aug 22, 2025

Brain Ventricular Microinjections of Lipopolysaccharide into Larval Zebrafish to Assess Neuroinflammation and Neurotoxicity
07:31

Brain Ventricular Microinjections of Lipopolysaccharide into Larval Zebrafish to Assess Neuroinflammation and Neurotoxicity

Published on: August 23, 2022

3.4K

Plasmalogens inhibit neuroinflammation and promote cognitive function.

Md Shamim Hossain1, Shiro Mawatari1, Takehiko Fujino1

  • 1Institute of Rheological Functions of Food, 2241-1 Kubara, Hisayama-machi, Kasuya-gun, Fukuoka 811-2501, Japan.

Brain Research Bulletin
|November 8, 2022
PubMed
Summary

Neuroinflammation, linked to Alzheimer's disease, reduces memory by decreasing special brain phospholipids called plasmalogens. Restoring plasmalogens may enhance memory and combat neuroinflammation.

Keywords:
AgingMemoryNeuro-inflammationNeurodegenerative diseasesPlasmalogens

More Related Videos

Improved 3D Hydrogel Cultures of Primary Glial Cells for In Vitro Modelling of Neuroinflammation
09:19

Improved 3D Hydrogel Cultures of Primary Glial Cells for In Vitro Modelling of Neuroinflammation

Published on: December 8, 2017

14.8K
Author Spotlight: Insight Into Advances in Prion Diseases Research
10:40

Author Spotlight: Insight Into Advances in Prion Diseases Research

Published on: August 11, 2023

550

Related Experiment Videos

Last Updated: Aug 22, 2025

Brain Ventricular Microinjections of Lipopolysaccharide into Larval Zebrafish to Assess Neuroinflammation and Neurotoxicity
07:31

Brain Ventricular Microinjections of Lipopolysaccharide into Larval Zebrafish to Assess Neuroinflammation and Neurotoxicity

Published on: August 23, 2022

3.4K
Improved 3D Hydrogel Cultures of Primary Glial Cells for In Vitro Modelling of Neuroinflammation
09:19

Improved 3D Hydrogel Cultures of Primary Glial Cells for In Vitro Modelling of Neuroinflammation

Published on: December 8, 2017

14.8K
Author Spotlight: Insight Into Advances in Prion Diseases Research
10:40

Author Spotlight: Insight Into Advances in Prion Diseases Research

Published on: August 11, 2023

550

Area of Science:

  • Neuroscience
  • Biochemistry

Background:

  • Neuroinflammation (NF) involves activated glial cells, common in neurodegenerative diseases like Alzheimer's disease (AD).
  • Increased NF impairs memory, but the underlying molecular mechanisms remain unclear.
  • Aging and NF reduce brain plasmalogens (Pls), crucial phospholipids, via NF-kB and c-MYC pathways.

Purpose of the Study:

  • To investigate the role of plasmalogens in memory regulation and neuroinflammation.
  • To explore the potential of plasmalogens as therapeutic agents for AD and related cognitive decline.

Main Methods:

  • Analysis of plasmalogen levels in murine and postmortem human brain tissues.
  • Investigating the signaling pathways (ERK, Akt, GPCRs) affected by plasmalogens.
  • Assessing the impact of plasmalogens on memory and neuroinflammation in AD models.

Main Results:

  • Plasmalogen levels are reduced in AD pathologies and aging brains.
  • Plasmalogens were found to enhance memory and reduce neuroinflammation in murine models.
  • Plasmalogens activate cellular signaling molecules ERK and Akt via GPCRs.

Conclusions:

  • Plasmalogens are key phospholipids in the brain that can enhance memory.
  • Plasmalogens play a critical role in inhibiting neuroinflammation.
  • Therapeutic strategies targeting plasmalogen levels may offer a novel approach for AD treatment.