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C1-based biomanufacturing: Advances, challenges and perspectives.

Xueqin Lv1, Wenwen Yu2, Chenyang Zhang2

  • 1Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, Jiangnan University, Wuxi 214122, China; Science Center for Future Foods, Jiangnan University, Wuxi 214122, China; Baima Future Foods Research Institute, Nanjing 211225, China.

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Summary
This summary is machine-generated.

One-carbon (C1) compounds offer sustainable feedstocks for biomanufacturing. This review covers C1 microbes, engineering strategies, and applications in producing biofuels and valuable chemicals, highlighting future research directions.

Keywords:
Adaptive laboratory evolutionC1 compoundsCofactor engineeringEnzyme engineeringGenome-scale modeling

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Area of Science:

  • Biotechnology
  • Metabolic Engineering
  • Synthetic Biology

Background:

  • One-carbon (C1) compounds are increasingly important as sustainable, non-food feedstocks for biomanufacturing.
  • Metabolic engineering and synthetic biology advancements drive the use of C1 compounds for energy-efficient and eco-friendly production.

Purpose of the Study:

  • To summarize and discuss current developments in C1 compound utilization for biomanufacturing.
  • To provide an overview of C1 microbes, engineering strategies, and applications.
  • To identify challenges and future research directions in C1-based biomanufacturing.

Main Methods:

  • Introduction and categorization of native and synthetic C1-utilizing microbes.
  • Compilation and review of engineering strategies for C1 utilization (pathway reconstruction, enzyme/cofactor engineering, modeling, evolution).
  • Review of C1 compound applications in synthesizing biofuels and high-value chemicals.

Main Results:

  • Summary of C1 microbe traits, categorization, and functions.
  • Detailed review of various engineering approaches to enhance C1 compound metabolism.
  • Overview of successful applications of C1 compounds in producing biofuels and valuable chemicals.

Conclusions:

  • C1 compounds represent a promising platform for sustainable biomanufacturing.
  • Effective engineering strategies are crucial for optimizing C1 utilization.
  • Further research is needed to overcome obstacles and advance C1-based biomanufacturing.