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Related Concept Videos

Cardiac Catheterization II: Right Heart Catheterization01:21

Cardiac Catheterization II: Right Heart Catheterization

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Right Heart Catheterization: An OverviewRight heart catheterization is an invasive diagnostic procedure that measures right-sided cardiac and pulmonary artery pressures, calculates cardiac output, and identifies intracardiac shunts. It provides detailed hemodynamic data essential for diagnosing and managing various cardiovascular conditions, such as pulmonary hypertension.Access SitesCommon access sites for right heart catheterization include the internal jugular vein in the neck region, the...
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Cardiac Catheterization III: Left Heart Catheterization01:24

Cardiac Catheterization III: Left Heart Catheterization

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Left heart catheterization is an invasive diagnostic procedure used to evaluate the function and structure of the left side of the heart. It is generally performed to diagnose and treat cardiovascular conditions such as valve abnormalities, coronary artery disease, and congenital heart defects.Diagnostic and therapeutic purposesLeft heart catheterization serves various diagnostic and therapeutic purposes, including:Assessing coronary artery bypass grafts.Evaluating coronary artery disease in...
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Cardiopulmonary Resuscitation III: AED Use01:23

Cardiopulmonary Resuscitation III: AED Use

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Introduction to AEDAn Automated External Defibrillator (AED) is a portable medical device that analyzes the heart's rhythm and, if necessary, delivers an electrical shock to help the heart re-establish an effective rhythm during sudden cardiac arrest (SCA). SCA occurs when the heart suddenly and unexpectedly stops beating, leading to a loss of blood flow to the brain and other vital organs. In such emergencies, time is of the essence, and using an AED, combined with Cardiopulmonary...
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Mechanical Ventilation II: Invasive Ventilation01:23

Mechanical Ventilation II: Invasive Ventilation

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Ventilators are essential medical equipment used to aid patients with respiratory difficulties. Their primary function is to assist or replace spontaneous breathing by providing mechanical ventilation. There are two general classes of mechanical ventilators: negative-pressure and positive-pressure ventilators.
Negative-Pressure Ventilators
Negative-pressure ventilators create a vacuum around the chest or body to draw air into the lungs, simulating breathing. This method does not require an...
240
Heart Failure I: Introduction01:27

Heart Failure I: Introduction

43
Heart failure refers to a clinical syndrome caused by structural or functional cardiac disorders that prevent the heart from pumping an adequate amount of blood to meet the body's metabolic needs. This condition often arises from myocardial infarction or ischemia, leading to decreased cardiac output, reduced tissue perfusion, impaired gas exchange, fluid volume imbalance, and decreased functional ability.Heart failure can result from disruptions in the mechanisms that regulate cardiac output...
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Mechanical Ventilation III: Noninvasive Ventilation01:23

Mechanical Ventilation III: Noninvasive Ventilation

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Noninvasive positive-pressure ventilation (NIPPV), continuous positive airway pressure (CPAP), and bilevel positive airway pressure (BiPAP) are essential methods in respiratory care. These ventilation techniques offer unique benefits for patients with various respiratory conditions, providing adequate support without requiring intubation. Let's explore how each method is crucial in improving patient outcomes and enhancing respiratory therapy.
Noninvasive Positive-Pressure Ventilation...
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Related Experiment Video

Updated: Aug 22, 2025

Use of a Percutaneous Ventricular Assist Device/Left Atrium to Femoral Artery Bypass System for Cardiogenic Shock
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COMPETENCE Trial: The EVAHEART 2 continuous flow left ventricular assist device.

Steven R Allen1, Mark S Slaughter2, Mustafa M Ahmed3

  • 1Penn State Health, Milton S. Hershey Medical Center, Hershey, Pennsylvania.

The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation
|November 8, 2022
PubMed
Summary
This summary is machine-generated.

The EVAHEART®2 (EVA2) left ventricular assist device may reduce adverse events in heart failure patients. The COMPETENCE Trial is evaluating if EVA2 is non-inferior to the HeartMate 3 LVAS.

Keywords:
COMPETENCE TrialLVADcardiac surgeryheart failuremechanical circulation support

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Area of Science:

  • Cardiology
  • Biomedical Engineering
  • Medical Devices

Background:

  • Continuous flow left ventricular assist devices (LVAS) improve outcomes for end-stage heart failure.
  • Existing LVAS have adverse event profiles limiting widespread use.
  • The EVAHEART®2 (EVA2) LVAS features large blood gaps and a non-protruding inflow cannula to potentially mitigate adverse events.

Purpose of the Study:

  • To assess the non-inferiority of the EVA2 LVAS compared to the HeartMate 3 LVAS (HM3) in patients with refractory advanced heart failure.
  • To evaluate the safety and efficacy of the EVA2 LVAS in mechanical circulatory support.

Main Methods:

  • A prospective, multi-center, randomized non-inferiority study (COMPETENCE Trial).
  • Primary endpoint: composite of survival to transplant/explant, freedom from disabling stroke, and freedom from severe right heart failure.
  • Randomization ratio of 2:1 (EVA2:HM3).

Main Results:

  • The first patient was enrolled in December 2020.
  • Currently, 25 subjects are enrolled (16 EVA2, 9 HM3).
  • Enrollment for the safety cohort is expected by Q3 2022, with an interim analysis planned.

Conclusions:

  • The EVA2's design, including its inflow cannula and large blood gaps, may enhance clinical outcomes.
  • The ongoing COMPETENCE trial will determine if the EVA2 is non-inferior to the HM3 LVAS.
  • Further studies are needed to fully understand the clinical benefits of the EVA2.