Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Aging01:26

Aging

151
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
151
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

2.2K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
2.2K
Bone Disorders01:29

Bone Disorders

3.8K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
3.8K
Mitochondria01:37

Mitochondria

14.2K
Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
14.2K
Lifestyle Factors and Health01:20

Lifestyle Factors and Health

109
Lifestyle factors play a critical role in maintaining overall health and preventing chronic diseases. Key elements, such as regular physical activity, a nutritious diet, and abstinence from smoking, can significantly enhance physical, mental, and emotional well-being while reducing the risk of several life-threatening conditions.
Benefits of Physical Activity
Physical activity, whether through structured exercise or casual activities like walking, biking, or dancing, is a cornerstone of a...
109
Menopause01:28

Menopause

232
Menopause, a natural biological process marking the end of a woman's fertility, typically occurs between the fifth and sixth decade of life. This phase is characterized by the exhaustion of the ovarian follicle pool, leading to less responsive ovaries despite the high levels of Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH). The consequential decrease in estrogen production results in symptoms like hot flashes, heavy sweating, headaches, hair loss, muscle pains, vaginal...
232

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Wisdom-inquiry science is essential for healthy longevity.

Age and ageing·2025
Same author

Climate geroscience: the case for 'wisdom-inquiry' science.

Biology letters·2024
Same author

The role of science communication in advancing translational gerontology.

Journal of the American Geriatrics Society·2024
Same author

Navigating the Landscape of Translational Geroscience in Canada: A Comprehensive Evaluation of Current Progress and Future Directions.

The journals of gerontology. Series A, Biological sciences and medical sciences·2024
Same author

Imagination and idealism after the COVID-19 pandemic: the science of healthy ageing.

Royal Society open science·2024
Same author

"Post-Protean" Public Health and the Geroscience Hypothesis.

Aging and disease·2023

Related Experiment Video

Updated: Aug 22, 2025

Surveying Low-Cost Methods to Measure Lifespan and Healthspan in Caenorhabditis elegans
10:08

Surveying Low-Cost Methods to Measure Lifespan and Healthspan in Caenorhabditis elegans

Published on: May 18, 2022

3.5K

Aging, Equality and the Human Healthspan.

Colin Farrelly1

  • 1Department of Political Studies, Queen's University, Kingston, ON, Canada. farrelly@queensu.ca.

HEC Forum : an Interdisciplinary Journal on Hospitals' Ethical and Legal Issues
|November 8, 2022
PubMed
Summary
This summary is machine-generated.

This essay critiques life extension ethics, proposing an egalitarian analysis focused on current health disparities and future intervention accessibility. It argues aging interventions are crucial public health advancements.

Keywords:
AgingEqualityHealthspanLife extension

More Related Videos

A Suppressor Screen for the Characterization of Genetic Links Regulating Chronological Lifespan in Saccharomyces cerevisiae
10:39

A Suppressor Screen for the Characterization of Genetic Links Regulating Chronological Lifespan in Saccharomyces cerevisiae

Published on: September 17, 2020

6.4K
Author Spotlight: Automated Lifespan Monitoring – Discovering Aging Dynamics with the Lifespan Machine
08:53

Author Spotlight: Automated Lifespan Monitoring – Discovering Aging Dynamics with the Lifespan Machine

Published on: January 26, 2024

1.2K

Related Experiment Videos

Last Updated: Aug 22, 2025

Surveying Low-Cost Methods to Measure Lifespan and Healthspan in Caenorhabditis elegans
10:08

Surveying Low-Cost Methods to Measure Lifespan and Healthspan in Caenorhabditis elegans

Published on: May 18, 2022

3.5K
A Suppressor Screen for the Characterization of Genetic Links Regulating Chronological Lifespan in Saccharomyces cerevisiae
10:39

A Suppressor Screen for the Characterization of Genetic Links Regulating Chronological Lifespan in Saccharomyces cerevisiae

Published on: September 17, 2020

6.4K
Author Spotlight: Automated Lifespan Monitoring – Discovering Aging Dynamics with the Lifespan Machine
08:53

Author Spotlight: Automated Lifespan Monitoring – Discovering Aging Dynamics with the Lifespan Machine

Published on: January 26, 2024

1.2K

Area of Science:

  • Gerontology
  • Bioethics
  • Public Health

Background:

  • Critically examines John Davis's ethical analysis of longevity science and life extension technologies.
  • Focuses on the impact of interventions on distinct societal groups: 'Haves', 'Have-nots', and 'Will-nots'.
  • Contrasts futuristic scenarios with present-day health vulnerabilities and inequalities in aging populations.

Purpose of the Study:

  • To offer a rival egalitarian analysis of gerontological interventions.
  • To assess the moral significance of applied aging interventions.
  • To advocate for aggressive funding of research into aging interventions.

Main Methods:

  • Critical examination of existing ethical frameworks for life extension.
  • Development of a novel egalitarian analysis considering current health inequalities.
  • Analysis of the fair diffusion of future aging interventions.

Main Results:

  • Aging is the primary risk factor for chronic diseases, frailty, and disability.
  • Over 2 billion individuals are projected to be over 60 by 2050.
  • An intervention slowing molecular and cellular aging could be a major 21st-century public health advancement.

Conclusions:

  • Aging interventions are ethically justifiable and beneficial.
  • Research into slowing the aging process should be aggressively funded.
  • Such interventions represent a critical advancement for public health, addressing widespread age-related decline.