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Technique for Isolation and Culture of Rat Jaw Bone Marrow Mesenchymal Stem Cells

Technique for Isolation and Culture of Rat Jaw Bone Marrow Mesenchymal Stem Cells

Published on: May 31, 2024

DPSC-Derived Extracellular Vesicles Promote Rat Jawbone Regeneration.

A E Lee¹, J G Choi^1,2, S H Shi¹

¹Department of Oral and Maxillofacial Surgery and Pharmacology, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Journal of Dental Research

|November 9, 2022

Summary

Extracellular vesicles from dental pulp stem cells promote jawbone regeneration. These cell-free vesicles enhance bone formation in vitro and in vivo, offering a promising approach for craniofacial bone repair.

Keywords:

exosome mandibular bone mesenchymal stem cell osteoinduction scaffolds tissue engineering

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The Establishment of a Murine Mandibular Molar Extraction Socket Healing Model

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Published on: January 13, 2023

Area of Science:

Regenerative Medicine
Biomaterials Science
Oral and Maxillofacial Surgery

Background:

Large jawbone defects pose significant challenges in head and neck surgery.
Tissue engineering and stem cell advancements are driving regenerative strategies for jawbone repair.
Mesenchymal stem cell-derived extracellular vesicles (EVs) exhibit therapeutic potential through trophic activities.

Purpose of the Study:

To investigate the osteogenic effects of dental pulp stem cell-derived EVs (DPSC-EVs) on jawbone marrow-derived MSCs (JB-MSCs) in vitro.
To evaluate the osteoinductive capacity of DPSC-EVs in a rat mandibular bone defect model in vivo.
To explore DPSC-EVs as a cell-free therapeutic option for craniofacial bone regeneration.

Main Methods:

In vitro: Cultured JB-MSCs treated with DPSC-EVs to assess gene expression (RUNX2, ALP, OCN) and osteogenic differentiation.
In vitro comparison: DPSC-EVs efficacy was compared to bone morphogenetic protein-2 (BMP-2).
In vivo: Mandibular bone defects in rats were treated with DPSC-EVs loaded onto a collagen membrane, followed by analysis of wound closure and new bone formation.

Main Results:

DPSC-EVs were efficiently uptaken by JB-MSCs, significantly promoting osteogenic gene expression and differentiation.
The in vitro osteogenic effect of DPSC-EVs was comparable to BMP-2.
In vivo, DPSC-EV treatment accelerated wound closure and increased new bone density in mandibular defects.

Conclusions:

DPSC-EVs demonstrate significant osteogenic and osteoinductive effects, supporting jawbone regeneration.
DPSC-EVs represent a promising cell-free therapeutic strategy for craniofacial bone defects.
The accessibility and properties of DPSCs make DPSC-EVs a viable option for regenerative therapies.