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Investigating the Pathogenesis of MYH7 Mutation Gly823Glu in Familial Hypertrophic Cardiomyopathy using a Mouse Model
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Investigating the Pathogenesis of MYH7 Mutation Gly823Glu in Familial Hypertrophic Cardiomyopathy using a Mouse Model

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Risk of incident mental disorders in hypertrophic cardiomyopathy: a nationwide propensity-matched study

Jun-Bean Park1,2, Je-Yeon Yun3,4, Bongsung Kim5

  • 1Department of Internal Medicine, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, 03080 Seoul, Republic of Korea.

European Journal of Preventive Cardiology
|November 9, 2022
PubMed

Insights

Patients with hypertrophic cardiomyopathy (HCM) have a significantly higher risk of developing mental disorders, especially within the first year after diagnosis. Early screening for conditions like mood and anxiety disorders is crucial for these individuals.

Area of Science:

  • Cardiology
  • Psychiatry
  • Epidemiology

Background:

  • Hypertrophic cardiomyopathy (HCM) is a complex cardiac condition.
  • Mental health comorbidities are increasingly recognized in chronic diseases.

Purpose of the Study:

  • To investigate the association between hypertrophic cardiomyopathy (HCM) and the subsequent risk of mental disorders.
  • To quantify the risk and temporal patterns of mental disorder development in HCM patients.

Main Methods:

  • Retrospective propensity score-matched cohort study.
  • Utilized nationwide Korean National Health Insurance Service data.
  • Followed 4046 HCM patients and 12138 matched controls for incident mental disorders.

Main Results:

  • HCM patients exhibited a 1.72-fold increased risk of incident mental disorders (HR: 1.719).
  • The risk was substantially elevated within the first month post-diagnosis (HR: 3.074), decreasing over time but remaining significant.
  • Increased risk observed for mood, anxiety, stress-related, and somatoform disorders.

Conclusions:

  • Hypertrophic cardiomyopathy is a significant risk factor for developing mental disorders.
  • Prompt mental health screening is essential for HCM patients, particularly within the first year of diagnosis.
  • Early identification and management of mood and anxiety disorders can improve patient outcomes.
Abstract

Keywords:
High-risk time windowHypertrophic cardiomyopathyMental disorders

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