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Prevalence of Iron Deficiency Anemia and Reference Range of Complete Blood Count, Reticulocyte Parameters in Infants
Harapan Parlindungan Ringoringo1
1Department of Child Health, Faculty of Medicine, Lambung Mangkurat University - RSD Idaman Banjarbaru, Banjarbaru, South Kalimantan, Indonesia.
Insights
Iron deficiency anemia (IDA) affects 32% of Indonesian infants aged 9-11 months. This study establishes crucial reference ranges for complete blood count (CBC) and reticulocyte parameters in this age group.
Area of Science:
- Pediatrics
- Hematology
- Public Health
Background:
- Iron deficiency anemia (IDA) remains a significant global health concern.
- Accurate diagnostic parameters, including complete blood count (CBC) and reticulocyte indices, are vital for disease identification.
Purpose of the Study:
- To determine the prevalence of IDA in Indonesian infants aged 9-11 months.
- To identify risk factors associated with IDA in this population.
- To establish reference ranges for CBC and key reticulocyte parameters (Ret-He, IRF, RPI) for healthy infants.
Main Methods:
- A prospective study involving 100 healthy infants aged 9-11 months was conducted in South Kalimantan, Indonesia.
- Data collection included CBC and reticulocyte parameter measurements.
- Statistical analysis was performed to determine prevalence, risk factors, and reference ranges.
Main Results:
- The prevalence of IDA was found to be 32% among the studied infants.
- No significant association was observed between IDA prevalence and maternal education, occupation, parity, family income, or infant nutritional status.
- Reference ranges for hemoglobin (Hb) and reticulocyte parameters were established for healthy infants.
Conclusions:
- The established reference ranges for CBC, Ret-He, IRF, and RPI provide a valuable benchmark for diagnosing conditions like IDA in healthy Indonesian infants aged 9-11 months.
- These findings can aid clinicians in the early detection and management of anemia in infants.
Background:
Iron deficiency anemia (IDA) is still a major global health problem. Determination of reference ranges for complete blood count (CBC), reticulocyte hemoglobin content (Ret-He), immature reticulocyte fraction (IRF), and reticulocyte production index (RPI) are essential to help diagnose a disease.
Purpose:
The study aims to know the prevalence of IDA, risk factors that influence it, and set a reference range for CBC and reticulocyte parameters in infants aged 9-11 months in Indonesia.
Patients And Methods:
The study was conducted prospectively at 10 Community Health Centers in Banjarbaru, South Kalimantan, Indonesia, from August 2020 to August 2021.
Results:
This study recruited 100 healthy infants (47% boys, 53% girls) aged 9-11 months. The prevalence of IDA was 32%. There is no association between IDA prevalence with the mother's education and occupation, maternal parity, family income, and infant nutritional status (p > 0.05). The reference range for hemoglobin (Hb) at P2.5-P97.5, P3-P97, P5-P95 and mean ± 2SD was 11.06 to 14.34 g/dL, 11.10 to 14.31 g/dL, 11.13 to 13.90 g/dL and 10.57 to 13.65 g/dL, respectively. This study also defined the reference ranges for reticulocyte parameters.
Conclusion:
The reference range of CBC, Ret-He, IRF, and RPI for healthy infants aged 9-11 months in this study can be used as a benchmark.
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