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Enhancement of IgE antibody formation in the rabbit by adrenergic antagonists
The effects of adrenergic antagonists on the humoral immune response of rabbits to egg albumin was studied. Propranolol, a beta-adrenergic antagonist, when administered at a dosage of 20 mg/kg of body weight, enhanced both passive hemagglutinating and IgE (passive cutaneous anaphylaxis) antibody formation. Phenoxybenzamine, an alpha-antagonist, at 0.4--40 mg/kg had a similar adjuvant effect. A marked delay in the immune response was noted with high dosages of phenoxybenzamine. Possible mechanisms of the adjuvant effects of these drugs are discussed.
The effects of adrenergic antagonists on the humoral immune response of rabbits to egg albumin was studied. Propranolol, a beta-adrenergic antagonist, when administered at a dosage of 20 mg/kg of body weight, enhanced both passive hemagglutinating and IgE (passive cutaneous anaphylaxis) antibody formation. Phenoxybenzamine, an alpha-antagonist, at 0.4--40 mg/kg had a similar adjuvant effect. A marked delay in the immune response was noted with high dosages of phenoxybenzamine. Possible mechanisms of the adjuvant effects of these drugs are discussed.