Fluorinated covalent organic frameworks for efficient drug delivery
Baiwei Ma1, Yimeng Xu1, Fujia Hu1
1School of Material and Chemical Engineering, Zhongyuan University of Technology Zhengzhou 450007 P. R. China zhailp@zut.edu.cn.
RSC Advances
|November 9, 2022
Summary
Two novel fluorine-functionalized covalent organic frameworks (COFs) show high drug loading and release capabilities. These COFs are effective and safe drug carriers, offering new possibilities for drug delivery systems.
Area of Science:
- Materials Science
- Nanotechnology
- Biomedical Engineering
Background:
- Covalent Organic Frameworks (COFs) are emerging porous materials with tunable properties.
- Developing efficient and biocompatible drug delivery systems is a significant challenge in medicine.
Purpose of the Study:
- To synthesize and characterize novel fluorine-functionalized COFs for drug delivery applications.
- To evaluate the drug loading capacity, release kinetics, and cellular uptake of these COFs.
Main Methods:
- Synthesis of DF-TAPB-COF and DF-TATB-COF.
- Characterization of COF structure, porosity, and pore size.
- Drug loading and release studies using 5-fluorouracil (5-FU).
- Cell viability assays (MTT) and cell endocytosis experiments.
Main Results:
- Successfully synthesized two novel fluorine-functionalized COFs (DF-TAPB-COF and DF-TATB-COF).
- COFs demonstrated excellent cell viability and high drug loading capacities, with DF-TAPB-COF achieving up to 69% drug loading for 5-FU.
- Efficient drug release was observed in simulated body fluid, and effective cellular endocytosis was confirmed.
Conclusions:
- Fluorine-functionalized COFs show great promise as effective and safe drug carriers.
- The designed COFs offer a new platform for advanced drug delivery systems.
- This research provides valuable insights for developing next-generation COF-based therapeutic carriers.
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