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Updated: Aug 22, 2025

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
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Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice

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Relationship between Blood Lipid Profiles and Risk of Lupus Nephritis in Children

Jiajia Liu1, Wenqi Song1, Dawei Cui2

  • 1Department of Clinical Laboratory Center, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China.

International Journal of Clinical Practice
|November 9, 2022
PubMed

Insights

Children with lupus nephritis (LN) often have dyslipidemia. High total cholesterol, triglycerides, and LDL-C levels are linked to LN risk in pediatric patients, necessitating careful lipid monitoring.

Area of Science:

  • Pediatric Rheumatology
  • Nephrology
  • Clinical Biochemistry

Background:

  • Systemic lupus erythematosus (SLE) is a common rheumatic disease in children.
  • Lupus nephritis (LN) is a severe complication of SLE, impacting renal function.
  • Blood lipid profiles in pediatric LN are not well-characterized.

Purpose of the Study:

  • To investigate the relationship between blood lipid profiles and the risk of developing LN in children.
  • To compare lipid metabolism characteristics between pediatric SLE patients with and without LN.
  • To identify specific lipid parameters associated with LN occurrence.

Main Methods:

  • A cohort of 134 newly diagnosed pediatric SLE patients was studied.
  • Patients were classified into LN and non-LN groups based on renal biopsy.
  • Clinical data and blood lipid profiles were analyzed and compared between groups.

Main Results:

  • The LN group showed higher anti-dsDNA antibody and SLEDAI, and lower C3/C4 levels.
  • Overall dyslipidemia incidence was 79.9%, significantly higher in the LN group.
  • Elevated total cholesterol (TC), triglycerides (TG), LDL-C, and VLDL-C were observed in the LN group; HDL-C showed no significant difference.
  • Lipid levels correlated positively with markers of renal damage (e.g., 24-hour urine protein, creatinine).
  • Combined TC, TG, LDL-C, and VLDL-C detection improved discrimination for LN risk.
  • Increased TC was an independent risk factor for LN.

Conclusions:

  • Pediatric LN patients exhibit significant dyslipidemia.
  • High TC, TG, LDL-C, and VLDL-C levels are strongly associated with LN development.
  • Close monitoring and management of blood lipid profiles are crucial for children with LN.
Abstract

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