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Relationship of plasma MBP and 8-oxo-dG with brain damage in preterm
Yuwei Zhao1, Guanghui Liu1, Lei Liang2
1Neonatology Department, Anhui Provincial Children Hospital, Hefei, China.
Insights
Myelin basic protein (MBP) and 8-oxo-deoxyguanosine (8-oxo-dG) serum levels can help diagnose brain injuries in premature infants. High MBP indicates white matter injury, while high 8-oxo-dG suggests white matter injury and hemorrhages.
Area of Science:
- Neonatal neurology
- Biomarker discovery
- Neuroprotection
Background:
- Preterm infants are susceptible to brain injury and long-term neurodevelopmental issues.
- Early diagnosis of brain injury in preterm infants is challenging due to a lack of specific clinical signs.
- Identifying reliable biomarkers is crucial for timely intervention and improved outcomes.
Purpose of the Study:
- To evaluate the diagnostic efficiency of serum myelin basic protein (MBP) and 8-oxo-deoxyguanosine (8-oxo-dG) levels for detecting brain injury in premature infants.
- To determine the correlation between these potential biomarkers and specific types of brain injury, including white matter injury (WMI) and periventricular-intraventricular hemorrhages (PIVH).
Main Methods:
- Prospective study including 75 preterm infants (gestational age 28-32 weeks, birth weight >1,000g).
- Measurement of serum MBP and 8-oxo-dG levels.
- Analysis of diagnostic accuracy using receiver operating characteristic (ROC) curves.
Main Results:
- Significantly elevated MBP serum levels were observed in preterm infants with WMI.
- Significantly increased 8-oxo-dG serum levels were found in infants with both WMI and PIVH.
- MBP and 8-oxo-dG showed a significant correlation, with ROC analysis yielding areas under the curve of 0.811 for MBP and 0.729 for 8-oxo-dG.
Conclusions:
- Elevated serum MBP levels may indicate white matter injury in preterm infants during the early postnatal period.
- Elevated serum 8-oxo-dG levels are associated with both white matter injury and periventricular-intraventricular hemorrhages.
- MBP and 8-oxo-dG show potential as novel neuro-markers for diagnosing brain injury in premature infants.
Abstract:
Preterm infants face a significant risk of brain injury in the perinatal period, as well as potential long-term neurodevelopmental disabilities. However, preterm children with brain injury lack specific clinical manifestations in the early days. Therefore, timely and accurate diagnosis of brain injury is of vital importance. This study was to explore the diagnostic efficiency of myelin basic protein (MBP) and 8-oxo-deoxyguanosine (8-oxo-dG) serum levels in brain injury of premature infants. A total of 75 preterm infants with gestational age between 28 and 32 weeks and birth weight higher than 1,000 g were prospectively included. MBP serum levels were significantly higher in premature infants with white matter injury (WMI). 8-oxo-dG serum levels were significantly increased in both WMI and periventricular-intraventricular hemorrhages (PIVH). MBP and 8-oxo-dG were significantly correlated. The area under the curve was 0.811 [95% confidence interval (CI) 0.667-0.955; p = 0.002] in MBP and 0.729 (95% CI 0.562-0.897; p = 0.020) in 8-oxo-dG. Therefore, the results showed that high MBP levels indicated a possibility of WMI in the premature brain during the early postnatal period, while high 8-oxo-dG levels were closely related to both WMI and PIVH, thus suggesting that MBP and 8-oxo-dG could be used as potential neuro-markers of preterm brain injury.
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