Related Experiment Video
Updated: Aug 22, 2025
Microsurgical Clip Obliteration of Middle Cerebral Aneurysm Using Intraoperative Flow Assessment
Published on: September 25, 2009
Risk Factors for Cerebrovascular Events in Moyamoya Angiopathy Using 4D Flow MRI: A Pilot Study
Maoxue Wang1, Yongbo Yang2, Wen Zhang1
1Department of Radiology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, Jiangsu, China.
Background:
Little is known about internal carotid artery (ICA) hemodynamics in patients with moyamoya angiopathy (MMA) and its role in cerebrovascular events.
Purpose:
To characterize ICA hemodynamics in MMA patients by 4D flow MRI and investigate its relationship with cerebrovascular events.
Study Type:
Prospective.
Subjects:
Seventy MMA patients (50 years old ± 9, 30 males).
Field Strength/Sequence:
Time-resolved three-directional velocity encoded fast field echo sequence (4D flow) MRI, T1-weighted fast field echo sequence, T2 weighted turbo spin echo sequence, diffusion weighted echo planar imaging; T2-weighted fluid-attenuated inversion recovery turbo spin echo sequence, susceptibility weighted fast field echo sequence, and time-of-flight MR angiography fast field echo sequence at 3.0T.
Assessment:
ICA hemodynamics (maximum and average velocity [Vmax , Vavg ], average blood flow [Flowavg ], and wall shear stress) were analyzed based on 4D flow data. Cerebral infarction, defined as the occurrence of events, in 124 brain hemispheres was determined according to clinical symptoms and conventional brain MR imaging.
Statistical Tests:
The independent-samples T test was used to evaluate differences in ICA hemodynamics between infarcted and non-infarcted hemispheres. Binary logistic regression was performed to investigate the relationship between ICA hemodynamics and events. A P value < 0.05 was considered statistically significant.
Results:
Sixty-one infarcted hemispheres (eight hemispheres with acute ischemic damage, 30 with chronic ischemic damage, and 23 with chronic hemorrhagic damage) had cerebrovascular events and 63 non-infarcted hemispheres did not. The hemodynamic parameters in the infarcted hemispheres (Vmax : P < 0.001; Vavg : P = 0.003; and Flowavg : P = 0.004) were significantly lower than those in the non-infarcted hemispheres. However, Vmax (P = 0.052), Vavg (P = 0.107), and Flowavg (P = 0.074) were not significantly different among hemispheres with acute ischemic lesions, chronic ischemic lesions and chronic hemorrhagic lesions. Vmax (odds ratio 3.033, 95% CI: 1.075-8.562) was independently associated with cerebrovascular events.
Data Conclusion:
Vmax maybe a higher risk factor of cerebrovascular events in MMA patients.
Evidence Level:
2 TECHNICAL EFFICACY STAGE: 3.
Insights
Maximum internal carotid artery velocity (Vmax) may indicate a higher risk of cerebrovascular events in moyamoya angiopathy (MMA) patients. This study characterized ICA hemodynamics using 4D flow MRI.
Area of Science:
- Neuroimaging
- Vascular Neurology
- Cardiovascular Imaging
Background:
- Internal carotid artery (ICA) hemodynamics in moyamoya angiopathy (MMA) are poorly understood.
- The role of ICA hemodynamics in cerebrovascular events in MMA patients requires further investigation.
Purpose of the Study:
- To characterize ICA hemodynamics in MMA patients using 4D flow MRI.
- To investigate the relationship between ICA hemodynamics and cerebrovascular events in MMA.
Main Methods:
- Prospective study involving 70 MMA patients (50 ± 9 years, 30 males).
- 4D flow MRI at 3.0T was used to analyze ICA hemodynamics, including maximum velocity (Vmax), average velocity (Vavg), average blood flow (Flowavg), and wall shear stress.
- Cerebral infarction in 124 brain hemispheres was assessed using clinical symptoms and conventional MRI.
Main Results:
- Hemodynamic parameters (Vmax, Vavg, Flowavg) were significantly lower in infarcted hemispheres compared to non-infarcted hemispheres (P < 0.001 for Vmax).
- No significant differences in Vmax, Vavg, or Flowavg were found among hemispheres with acute ischemic, chronic ischemic, or chronic hemorrhagic lesions.
- Vmax was independently associated with cerebrovascular events (odds ratio 3.033, 95% CI: 1.075-8.562).
Conclusions:
- Maximum internal carotid artery velocity (Vmax) may serve as a significant risk factor for cerebrovascular events in patients with moyamoya angiopathy.
- 4D flow MRI is a valuable tool for assessing ICA hemodynamics in MMA and identifying potential risks.
More Related Videos
05:23Author Spotlight: Noninvasive Cerebral Blood Flow Determination in Human Functional Brain Region for Diagnosis of Neurological Disorders
Published on: May 31, 2024
13:01Intraluminal Middle Cerebral Artery Occlusion MCAO Model for Ischemic Stroke with Laser Doppler Flowmetry Guidance in Mice
Published on: May 8, 2011
