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Updated: Aug 22, 2025

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Antibiotic Dereplication Using the Antibiotic Resistance Platform
Published on: October 17, 2019
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The substrate scope of dehydratases in antibiotic biosynthesis and their application in kinetic resolutions
Zhiyong Yin1, Daniel Bär2, Bertolt Gust2
1Kekulé-Institute for Organic Chemistry and Biochemistry, University of Bonn, Gerhard-Domagk-Straße 1, 53121 Bonn, Germany. dickschat@uni-bonn.de.
Organic & Biomolecular Chemistry
|November 9, 2022
Abstract:
Nine dehydratases involved in the biosynthesis of secondary metabolites in addition to FabZ from fatty acid biosynthesis were investigated for their substrate scope using a panel of N-acetylcysteamine (SNAC) thioesters. The best performing enzyme BorDH2 was applied in kinetic resolutions.

