Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same authorSame journal

Electrospun aligned nanofibers for tissue engineering.

Biomaterials science·2026
Same author

Recombinant Human Nerve Growth Factor in Pediatric Neuropathic Keratopathy: A Focus on Corneal Opacities, Amblyopia, and Visual Outcomes.

Cornea·2026
Same author

Retinal Blood Velocity after Intravitreal Injection for Neovascular Age-Related Macular Degeneration with Optical Coherence Tomography Using Speckle Analysis.

Retina (Philadelphia, Pa.)·2026
Same author

Besifloxacin-eluting contact lens with sustained drug delivery and enhanced bioavailability.

International journal of pharmaceutics: X·2026
Same author

Correction: Ciprofloxacin-loaded bioadhesive hydrogels for ocular applications.

Biomaterials science·2026
Same author

Clinical Characteristics of Ocular Graft-Versus-Host Disease Associated With Tapering of Immunosuppressive Drugs.

Cornea·2026

Related Experiment Video

Updated: Aug 22, 2025

Development of an In Vitro Ocular Platform to Test Contact Lenses
08:28

Development of an In Vitro Ocular Platform to Test Contact Lenses

Published on: April 6, 2016

10.7K

Development and optimization of an ocular hydrogel adhesive patch using definitive screening design (DSD).

Shima Gholizadeh1, Xi Chen1, Ann Yung2

  • 1Chemical and Biomolecular Engineering Department, University of California - Los Angeles, Los Angeles, CA, USA. nannabi@ucla.edu.

Biomaterials Science
|November 9, 2022
PubMed
Summary

This study optimized GelPatch, a photocrosslinkable adhesive hydrogel, for ocular tissue repair. The developed GelPatch demonstrates excellent adhesion and retention on the sclera and subconjunctival tissue for up to four days.

More Related Videos

An Optimized O9-1/Hydrogel System for Studying Mechanical Signals in Neural Crest Cells
11:02

An Optimized O9-1/Hydrogel System for Studying Mechanical Signals in Neural Crest Cells

Published on: August 13, 2021

3.1K
Hydrogel Arrays Enable Increased Throughput for Screening Effects of Matrix Components and Therapeutics in 3D Tumor Models
10:49

Hydrogel Arrays Enable Increased Throughput for Screening Effects of Matrix Components and Therapeutics in 3D Tumor Models

Published on: June 16, 2022

2.6K

Related Experiment Videos

Last Updated: Aug 22, 2025

Development of an In Vitro Ocular Platform to Test Contact Lenses
08:28

Development of an In Vitro Ocular Platform to Test Contact Lenses

Published on: April 6, 2016

10.7K
An Optimized O9-1/Hydrogel System for Studying Mechanical Signals in Neural Crest Cells
11:02

An Optimized O9-1/Hydrogel System for Studying Mechanical Signals in Neural Crest Cells

Published on: August 13, 2021

3.1K
Hydrogel Arrays Enable Increased Throughput for Screening Effects of Matrix Components and Therapeutics in 3D Tumor Models
10:49

Hydrogel Arrays Enable Increased Throughput for Screening Effects of Matrix Components and Therapeutics in 3D Tumor Models

Published on: June 16, 2022

2.6K

Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Ophthalmology

Background:

  • Chemically modified photocrosslinkable polymers form adhesive hydrogels for wound sealing.
  • These hydrogels offer tunable properties like tissue adhesion, mechanical strength, swelling, and degradation.

Purpose of the Study:

  • To develop and optimize a photocrosslinkable adhesive patch, GelPatch, for ocular tissue adhesion.
  • To achieve high burst pressure, minimal swelling, and specific mechanical properties for scleral and subconjunctival applications.

Main Methods:

  • Formulation of hydrogel patches using polymers with varying methacrylation, molecular weights, and hydrophobicity/hydrophilicity.
  • Utilized a definitive screening design (DSD) analysis to identify key components impacting adhesion, swelling, and elastic modulus.
  • Mathematical modeling to predict correlations between formulation factors and response parameters.

Main Results:

  • An optimized GelPatch formulation was identified using gelatin methacryloyl (GelMA) and glycidyl methacrylated hyaluronic acid (HAGM).
  • Ex vivo studies confirmed successful adhesion and retention of the hydrogel on scleral and subconjunctival tissues for up to 4 days.
  • The optimized formulation exhibited high burst pressure and minimal swelling.

Conclusions:

  • The optimized GelPatch formulation shows significant potential as an ocular sealant.
  • It offers a promising solution for the rapid repair of laceration-type ocular injuries.
  • Further clinical evaluation is warranted to confirm efficacy in human patients.