Related Experiment Video
Updated: Aug 22, 2025
04:22
Application of Laparoscopic Hepatectomy Combined with Intraoperative Microwave Ablation in Colorectal Cancer Liver Metastasis
Published on: March 3, 2023
504
Health-Related Quality of Life Following Simultaneous Resection for Synchronous Colorectal Cancer Liver Metastases
C D Griffiths1, P Karanicolas2,3, S Gallinger2,4
1Department of Surgery, McMaster University, Hamilton, ON, Canada.
Annals of Surgical Oncology
|November 9, 2022
Summary
Simultaneous resection for colorectal liver metastases significantly worsened patient role functioning and increased fatigue, persisting 12 weeks post-surgery. Quality of life impacts require careful consideration for this surgical approach.
Area of Science:
- Oncology
- Surgical Oncology
- Health Outcomes Research
Background:
- Synchronous colorectal liver metastases (SCLM) are present in up to 25% of patients.
- Treatment options include staged or simultaneous resection, with similar morbidity/mortality.
- Health-related quality of life (HRQoL) post-simultaneous resection is not well-documented.
Purpose of the Study:
- To assess the feasibility and impact on HRQoL of simultaneous resection for SCLM.
- To evaluate changes in patient-reported outcomes following this surgical approach.
Main Methods:
- Prospective feasibility trial involving simultaneous resection of SCLM.
- Patients completed European Organization for Research and Treatment of Cancer (EORTC) QLQ-C30 and LMC21 questionnaires.
- Validated minimally important clinical difference (MICD) of 10 points used for analysis.
Main Results:
- High completion rates for QLQ-C30 (95% baseline, 83% 12 weeks) and LMC21 (95% baseline, 80% 12 weeks).
- Significant worsening in physical functioning, role functioning, and increased pain at 4 weeks post-surgery.
- Persistent significant worsening in role functioning and fatigue at 12 weeks; physical functioning and pain returned to baseline.
Conclusions:
- Simultaneous resection of SCLM leads to a clinically significant decline in HRQoL.
- Worsening fatigue and role functioning persist at 12 weeks post-operation.
- These findings highlight the need to consider long-term HRQoL impacts in treatment decisions for SCLM.
