lncRNASNP v3: an updated database for functional variants in long non-coding RNAs
Yanbo Yang1, Dongyang Wang1, Ya-Ru Miao2
1Hubei Key Laboratory of Agricultural Bioinformatics, College of Informatics, Huazhong Agricultural University, Wuhan 430070, China.
Nucleic Acids Research
|November 9, 2022
Summary
The updated lncRNASNP v3 database now includes millions of single nucleotide polymorphisms (SNPs) and mutations across eight species, detailing their impact on long non-coding RNA (lncRNA) function and disease associations.
Area of Science:
- Genomics
- Molecular Biology
- Bioinformatics
Background:
- Long non-coding RNAs (lncRNAs) are crucial regulators of biological processes and disease.
- Single nucleotide polymorphisms (SNPs) and somatic mutations within lncRNAs can alter their structure and function.
- Previous versions of the lncRNASNP database have cataloged these variants, but require updating due to new discoveries.
Purpose of the Study:
- To update and expand the lncRNASNP database (v3) with comprehensive data on lncRNA variants and their functional impacts.
- To increase the number of species covered and incorporate new features for enhanced data analysis.
- To provide an updated resource for researchers studying lncRNAs in health and disease.
Main Methods:
- Expanded the database to include eight eukaryotic species.
- Integrated updated SNP and mutation data, significantly increasing the total count.
- Added new features including SNP effects on miRNA-lncRNA interactions, expression profiles, disease/GWAS associations, drug targets, and eQTL data.
Main Results:
- lncRNASNP v3 now contains 67,513,785 SNPs and 2,387,685 human mutations.
- The database covers eight species and includes comprehensive data on variant impacts.
- New features facilitate the study of lncRNA function, disease links, and therapeutic potential.
Conclusions:
- lncRNASNP v3 is a significantly expanded and feature-rich resource for lncRNA variant research.
- The database supports a deeper understanding of lncRNA roles in biological processes and diseases.
- This updated resource is freely available to the scientific community.
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