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Updated: Aug 22, 2025
07:44
Identifying Protein-protein Interaction Sites Using Peptide Arrays
Published on: November 18, 2014
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InterPro in 2022
Typhaine Paysan-Lafosse1, Matthias Blum1, Sara Chuguransky1
1European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SD, UK.
Nucleic Acids Research
|November 9, 2022
Summary
The InterPro database now offers enriched protein family classifications and improved website access. Updates include integrating Pfam features and exploring AI for protein structure prediction.
Area of Science:
- Bioinformatics
- Computational Biology
- Protein Science
Background:
- The InterPro database integrates protein sequence classifications, identifying functional domains and conserved sites.
- Protein sequence analysis is crucial for understanding protein function and evolution.
Purpose of the Study:
- To report recent developments in the InterPro database (version 90.0) and associated software.
- To enhance data content, website usability, and integrate features from the retiring Pfam database.
- To assess InterPro's sequence coverage growth relative to UniProtKB and explore public engagement strategies.
Main Methods:
- Database updates and software enhancements for InterPro version 90.0.
- Integration of Pfam website features into the InterPro platform.
- Comparative analysis of InterPro sequence coverage against UniProtKB growth.
- Development of a card game for public engagement with protein science.
Main Results:
- InterPro version 90.0 includes updated data content and a more user-friendly website.
- Pfam website features are being migrated to InterPro, with the Pfam site retiring in late 2022.
- InterPro's sequence coverage has successfully scaled with the expansion of UniProtKB.
- A novel card game has been developed to engage the non-scientific community.
Conclusions:
- Recent developments enhance InterPro's utility and accessibility for protein sequence analysis.
- The integration of Pfam data strengthens InterPro as a comprehensive resource.
- InterPro maintains robust coverage, keeping pace with the growing volume of protein sequence data.
- Innovative outreach methods, like the card game, can broaden public engagement with complex scientific concepts.
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