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In vivo gene immunotherapy for cancer

David Mai1,2, Carl H June1,3, Neil C Sheppard1,3

  • 1Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, PA 19104, USA.

Science Translational Medicine
|November 9, 2022
PubMed

Insights

Cancer involves immune system dysfunction, necessitating personalized therapies. Advances in gene modulation and delivery technologies are paving the way for in vivo precision medicine to combat cancer.

Area of Science:

  • Immunology
  • Oncology
  • Biotechnology

Background:

  • Cancer is increasingly recognized as a disease involving immune system dysfunction alongside pathological cells.
  • The unique and patient-specific characteristics of cancer highlight the need for personalized cellular treatments.
  • Current personalized cellular therapies are primarily produced outside the body (ex vivo).

Purpose of the Study:

  • To explore the potential of gene-modulating technologies for cancer treatment.
  • To discuss the shift towards in vivo precision medicine for cancer.
  • To highlight advancements in therapeutic RNA and viral vector delivery systems.

Main Methods:

  • Review of gene-modulating approaches, including therapeutic RNAs and viral vectors.
  • Analysis of trends in simplifying personalized cancer therapies.
  • Exploration of in vivo precision medicine strategies.

Main Results:

  • Gene-modulating technologies are advancing the development of cancer mitigation strategies.
  • Improved delivery systems enhance the potential for altering gene expression in immune cells.
  • Simplification of personalized therapies is enabling new treatment avenues.

Conclusions:

  • Personalized cellular therapies are crucial for heterogeneous cancers.
  • Therapeutic RNAs and viral vectors offer promising avenues for immune cell modulation.
  • Emerging technologies support the future of direct, in vivo precision medicine for cancer treatment.

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