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Updated: Aug 22, 2025

The Mouse Round-window Approach for Ototoxic Agent Delivery: A Rapid and Reliable Technique for Inducing Cochlear Cell Degeneration

The Mouse Round-window Approach for Ototoxic Agent Delivery: A Rapid and Reliable Technique for Inducing Cochlear Cell Degeneration

Published on: November 26, 2015

Does Hypochlorous Acid Cause Ototoxicity? An Experimental Study.

Ahmet Mutlu, Ayşe Yasemin Gunduz, Burcu Bakici Balci

¹Department of Audiology, Faculty of Health Sciences, İstanbul Medeniyet University, İstanbul.

Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [And] European Academy of Otology and Neurotology

|November 9, 2022

Summary

This summary is machine-generated.

Hypochlorous acid (HOCl) shows less ototoxicity than other disinfectants but can still harm the cochlea. Further research is needed to evaluate HOCl safety in otologic applications.

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Area of Science:

Ototoxicology
Pharmacology
Histopathology

Background:

Hypochlorous acid (HOCl) is an antiseptic with low toxicity to living tissues.
Its ototoxic effects, particularly in otologic applications, require thorough investigation.

Purpose of the Study:

To evaluate the ototoxic effects of HOCl on an animal model.
To compare HOCl's ototoxicity with other common otologic disinfectants.

Main Methods:

32 Sprague-Dawley rats were divided into control, saline, isopropyl alcohol + chlorhexidine, and HOCl groups.
Auditory brainstem response (ABR) was used to assess hearing thresholds before and after intratympanic injections.
Cochlear histology and immunohistochemistry were performed post-mortem.

Main Results:

HOCl demonstrated less hearing deterioration compared to isopropyl alcohol + chlorhexidine.
HOCl induced partial hearing recovery by day 21.
Histopathology revealed cochlear degeneration in both HOCl and isopropyl alcohol + chlorhexidine groups.

Conclusions:

HOCl is less ototoxic than isopropyl alcohol + chlorhexidine but may still cause cochlear toxicity.
This study is the first to assess HOCl safety in otology, highlighting the need for careful consideration in clinical use.