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Related Concept Videos

Neuroplasticity01:01

Neuroplasticity

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Neuroplasticity reflects the brain's remarkable capacity to adapt and evolve, responding dynamically to learning, experiences, or injury by reorganizing its neural circuitry. This reorganization involves creating new neural connections and refining old ones through a series of biological processes that contribute to the brain's lifelong development and adaptability.
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CNS Stimulants: Psychedelic Agents01:22

CNS Stimulants: Psychedelic Agents

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Hallucinogens, also known as psychedelic drugs, are a class of substances known for their ability to alter perception, cognition, and emotions. Despite their profound effects on the mind, these drugs are non-addictive, setting them apart from many other abused substances. The mechanism of action of these drugs lies in their impact on the 5-HT2A receptor in the brain. Upon activation, this receptor couples to Gq-type G proteins, triggering a cascade that releases intracellular calcium. This...
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Hallucinogens and Psychedelics01:27

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Hallucinogens are psychoactive substances that profoundly alter perceptual experiences, generating unreal visual and sensory images. Often referred to as psychedelic drugs — a term derived from the Greek words "psyche" (mind) and "delos" (revealing) — these substances include marijuana and lysergic acid diethylamide (LSD), among others. These drugs vary in intensity and effects.
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Altered States of Awareness01:06

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Altered states of consciousness represent significant deviations from one's normal mental state. These deviations can range from subtle changes in awareness to profound transformations in perception, thought processes, and sensory experiences. Altered states of consciousness can be triggered by various factors, including drug use, meditation, hypnosis, illness, or even intense fatigue.
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An Overview of Psychoactive Drugs01:28

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Psychoactive drugs impact brain function, influencing perception, mood, consciousness, cognition, and behavior. These substances are grouped based on their effects and the mechanisms by which they act.
Stimulants such as cocaine, amphetamines, and nicotine enhance brain activity, leading to increased alertness, attention, and energy. These drugs typically raise heart rate, blood pressure, and body temperature. While they can induce feelings of euphoria, their misuse can result in severe health...
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Long-term Potentiation01:35

Long-term Potentiation

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Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre- and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
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Psychedelics and Neural Plasticity: Therapeutic Implications.

Steven F Grieco1, Eero Castrén2, Gitte M Knudsen3

  • 1Department of Anatomy and Neurobiology, School of Medicine, University of California, Irvine, California 92697.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
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PubMed
Summary

Psychedelic drugs show promise for treating brain disorders by inducing neural plasticity. Ongoing research explores their mechanisms, receptor binding, and effects on brain circuits for clinical applications.

Keywords:
5-HT2ARcircuitsplasticitypsychedelicspsychoplastogens

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Area of Science:

  • Neuroscience
  • Psychopharmacology
  • Clinical Research

Background:

  • Psychedelic drugs are being re-investigated for treating brain disorders.
  • Cultural acceptance and scientific interest in psychedelics are growing.
  • Hundreds of clinical trials were underway in 2022 for psychedelic therapies.

Purpose of the Study:

  • To showcase basic and clinical research on psychedelic mechanisms.
  • To elucidate how psychedelics impact neural plasticity.
  • To review the translation of psychedelic research to clinical practice.

Main Methods:

  • Review of psychedelic receptor binding sites.
  • Analysis of psychedelic effects on gene expression.
  • Examination of psychedelic impacts on neural microcircuitry and brain-wide circuits.

Main Results:

  • Emerging evidence suggests psychedelics induce structural and functional neural plasticity.
  • Research covers receptor interactions, genetic effects, and circuit-level alterations.
  • The study highlights ongoing efforts to understand psychedelic therapeutic potential.

Conclusions:

  • Psychedelics may offer long-lasting therapeutic effects through neural plasticity.
  • Further basic neuroscience research is needed to address clinical needs.
  • Translational challenges and future research directions are discussed.