Chromosomal polymorphisms have no negative effect on reproductive outcomes after IVF/ICSI-ET/FET

Area of Science:

• Reproductive Medicine
• Human Genetics

Background:

• Chromosomal polymorphisms (CPs) are variations in chromosome structure.
• Their impact on assisted reproductive technology (ART) outcomes, including IVF/ICSI-ET and FET, requires clarification.

Purpose of the Study:

• To investigate the association between parental chromosomal polymorphisms and reproductive outcomes in ART cycles.
• To determine if uniparental or biparental CPs affect key metrics like implantation, clinical pregnancy, live birth, and early miscarriage rates.

Main Methods:

• Retrospective analysis of 21,867 ART cycles (fresh and FET).
• Cycles were categorized based on the presence of CPs in males, females, or couples without CPs.
• Comparison of implantation rate (IR), clinical pregnancy rate (CPR), live birth rate (LBR), and early miscarriage rate (EMR) across groups.

Main Results:

• In fresh IVF/ICSI-ET cycles, CPR and LBR showed no significant differences between groups with male, female, or no CPs.
• In FET cycles, IR, CPR, EMR, and LBR were not significantly different among groups with male, female, or no CPs.
• CPs were not independently associated with CPR or LBR in either fresh or FET cycles.

Conclusions:

• Uniparental chromosomal polymorphisms do not appear to negatively affect IVF/ICSI-ET or FET outcomes.
• Factors such as female age and embryo quality are more significantly associated with successful pregnancy outcomes.
• The effect of biparental CPs on pregnancy outcomes remains undetermined.