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Updated: Aug 22, 2025

Optimizing Photoneuromodulation Techniques to Evaluate the Role of Green Light-Emitting Diodes in Pain Management
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Gpr83 Tunes Nociceptor Function, Controlling Pain.

Yerin Kim1, Chaeeun Kim1, Hojin Lee1

  • 1Department of Biomedical Sciences, Korea University College of Medicine, Seoul, 02841, Korea.

Neurotherapeutics : the Journal of the American Society for Experimental Neurotherapeutics
|November 10, 2022
PubMed
Summary
This summary is machine-generated.

Researchers identified G protein-coupled receptor 83 (Gpr83) as a key player in pain signaling. Silencing Gpr83 in sensory neurons reduced pain responses, suggesting it as a potential target for new pain relief medications.

Keywords:
AnalgesiaGpr83NociceptorPENPain

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Area of Science:

  • Neuroscience
  • Pharmacology
  • Pain Research

Background:

  • Peripheral nociceptors are modulated by G protein-coupled receptors (GPRs), influencing pain perception.
  • Understanding novel GPRs involved in pain is crucial for developing new analgesic strategies.

Purpose of the Study:

  • To investigate the role of Gpr83, a previously unrecognized GPR, in peripheral pain modulation.
  • To explore Gpr83 as a potential therapeutic target for pain management.

Main Methods:

  • Analysis of Gene Expression Omnibus (GEO) metadata to assess Gpr83 expression in the peripheral nervous system.
  • Immunohistochemistry on murine dorsal root ganglia (DRG) to confirm Gpr83 localization.
  • Gpr83 gene silencing in DRG neurons to evaluate its effect on nociception.
  • In vivo and in vitro studies using Gpr83 ligand PEN to assess pain responses.

Main Results:

  • Gpr83 is highly expressed in the peripheral nervous system, particularly in DRG.
  • Gpr83 knockdown in DRG significantly downregulated neuronal and behavioral nociception.
  • Gpr83 silencing alleviated pathological pain in models of hind paw inflammation and chemotherapy-induced peripheral neuropathy.
  • In vitro, PEN showed differential effects on nociceptor responses based on exposure time; in vivo, localized PEN administration mitigated pain.

Conclusions:

  • Gpr83 plays a significant role in tuning peripheral pain sensitivity.
  • Gpr83 is a potential GPR target for developing novel pain modulation therapies.