Related Experiment Video

Updated: Aug 22, 2025

Scanning Electron Microscopy of Macerated Tissue to Visualize the Extracellular Matrix
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Published on: June 14, 2016

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Subclinical HMOD in Hypertension: Left Ventricular Diastolic Dysfunction

Fabio Bertacchini1, Claudia Agabiti Rosei1, Giacomo Buso1

  • 1Department of Clinical and Experimental Sciences, 2a Medicina-ASST Spedali Civili Brescia, University of Brescia, 25100, Brescia, Italy.

High Blood Pressure & Cardiovascular Prevention : the Official Journal of the Italian Society of Hypertension
|November 10, 2022
PubMed

Insights

Arterial hypertension can cause organ damage, particularly affecting the heart. This review details diagnosing and treating diastolic dysfunction, a key indicator of hypertension-related cardiac changes.

Area of Science:

  • Cardiology
  • Nephrology
  • Vascular Medicine

Background:

  • Arterial hypertension is a major risk factor for cardiovascular, cerebrovascular, and renal events.
  • Hypertension-induced organ damage (HMOD) has prognostic importance and impacts treatment decisions.
  • Cardiac structure and function alterations are the most frequently evaluated HMOD.

Purpose of the Study:

  • To review diagnostic methods for diastolic dysfunction.
  • To discuss the prognostic significance of diastolic dysfunction in hypertension.
  • To outline treatment strategies for diastolic dysfunction.

Main Methods:

  • Literature review of diagnostic tools for diastolic dysfunction.
  • Analysis of studies on the prognostic value of diastolic dysfunction.
  • Synthesis of current treatment guidelines for hypertension-related diastolic dysfunction.

Main Results:

  • Diastolic dysfunction is a common manifestation of HMOD.
  • Early detection and management of diastolic dysfunction are crucial.
  • Treatment of hypertension and diastolic dysfunction can improve outcomes.

Conclusions:

  • Diastolic dysfunction is a significant HMOD with prognostic implications.
  • Comprehensive assessment and tailored treatment are essential for hypertensive patients.
  • Addressing diastolic dysfunction is key to preventing adverse cardiovascular events.

Keywords:
Antihypertensive treatmentArterial hypertensionDiastolic dysfunctionHeart failure preserved ejection fraction

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