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Bone-kidney axis: A potential therapeutic target for diabetic nephropathy
Ming Yang1,2, Shilu Luo2, Jinfei Yang2
1Department of Nutrition, Xiangya Hospital, Central South University, Changsha, China.
Frontiers in Endocrinology
|November 10, 2022
Summary
Diabetic nephropathy (DN) pathogenesis is unclear, hindering effective treatments. This review explores the "bone-kidney axis," suggesting bone-derived proteins offer potential targets for DN diagnosis and therapy.
Area of Science:
- Endocrinology
- Nephrology
- Bone Biology
Background:
- Diabetic nephropathy (DN) is a major cause of end-stage renal disease (ESRD).
- The pathogenesis of DN is not fully understood, and current treatments are limited.
- Organ cross-talk is increasingly recognized as crucial in disease development.
Purpose of the Study:
- To review bone composition and changes in DN.
- To summarize bone-derived proteins and their role in DN progression.
- To propose the "bone-kidney axis" as a potential therapeutic target.
Main Methods:
- Literature review of studies on bone metabolism and kidney disease.
- Analysis of endocrine functions of bone-derived proteins.
- Discussion of the interaction between bone and kidney in DN.
Main Results:
- Bone structure and function are altered in diabetic nephropathy.
- Bone-derived proteins can influence kidney homeostasis.
- The "bone-kidney axis" plays a role in DN pathogenesis.
Conclusions:
- The "bone-kidney axis" represents a novel area for understanding DN.
- Bone-derived factors are implicated in the progression of diabetic nephropathy.
- Targeting the "bone-kidney axis" may offer new avenues for DN diagnosis and treatment.
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