Related Experiment Video
Updated: Aug 22, 2025

Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances
Published on: October 11, 2018
An expectation maximization algorithm for high-dimensional model selection for the Ising model with misclassified
David G Sinclair1, Giles Hooker1
1Department of Statistical Science, Cornell University, Ithaca, NY, USA.
Abstract:
We propose the misclassified Ising Model: a framework for analyzing dependent binary data where the binary state is susceptible to error. We extend previous theoretical results of a model selection method based on applying the LASSO to logistic regression at each node and show that the method will still correctly identify edges in the underlying graphical model under suitable misclassification settings. With knowledge of the misclassification process, an expectation maximization algorithm is developed that accounts for misclassification during model selection. We illustrate the increase of performance of the proposed expectation maximization algorithm with simulated data, and using data from a functional magnetic resonance imaging analysis.
Related Concept Videos
Mechanistic Models: Compartment Models in Algorithms for Numerical Problem Solving
In individual population analyses, different algorithms are employed, such as Cauchy's method, which uses a...
One-Compartment Open Model: Wagner-Nelson and Loo Riegelman Method for ka Estimation
On...
Expected Frequencies in Goodness-of-Fit Tests
Mechanistic Models: Compartment Models in Individual and Population Analysis
Pharmacokinetic Models: Comparison and Selection Criterion
Physiological models take a detailed approach by considering specific molecular processes. They can predict drug distribution, metabolism, and elimination changes, providing a comprehensive understanding of how drugs interact with the body.
Parameters Affecting Nonlinear Elimination: Zero-Order Input, First-Order Absorption and Two-Compartment Model
When a drug is administered through a constant intravenous infusion and eliminated via nonlinear pharmacokinetics, it follows zero-order input. For example, oral drugs undergo first-order absorption upon administration and are eliminated through nonlinear pharmacokinetics.
In the case of subcutaneously administered drugs,...

