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Updated: Aug 22, 2025

Stenosis of the Inferior Vena Cava: A Murine Model of Deep Vein Thrombosis
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Stenosis of the Inferior Vena Cava: A Murine Model of Deep Vein Thrombosis

Published on: December 22, 2017

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Mortality and Deep Vein Thrombosis in the Gamma Variant of Covid 19 and Lung Injury

Carolina Hungaro Cunha1, Debora Yuri Sato1, Jose Maria Pereira de Godoy2

  • 1Ecography Service in Hospital de Base-FUNFARME/FAMERP, Sao Jose do Rio Preto, Brazil.

Vascular Health and Risk Management
|November 10, 2022
PubMed

Insights

Deep vein thrombosis worsens mortality in COVID-19 patients. The Gamma variant of SARS-CoV-2 increases both thrombosis and death rates, highlighting critical risk factors.

Area of Science:

  • Pulmonary Medicine
  • Infectious Diseases
  • Hematology

Background:

  • SARS-CoV-2 infection is linked to thrombosis, but mechanisms remain unclear.
  • Coagulation balance is crucial for managing critically ill COVID-19 patients.
  • Understanding thrombosis in COVID-19 is vital for preventing complications.

Purpose of the Study:

  • Investigate pulmonary injury patterns in COVID-19 patients with deep vein thrombosis (DVT).
  • Compare mortality and lung injury in COVID-19 patients with and without DVT.
  • Determine the impact of the SARS-CoV-2 Gamma variant on DVT and mortality.

Main Methods:

  • Retrospective study of 200 COVID-19 patients with suspected DVT in an ICU.
  • Patients categorized into DVT-positive and DVT-negative groups.
  • Statistical analysis using Fisher's exact test, paired t-test, and chi-square test.

Main Results:

  • DVT patients exhibited significantly more severe lung injuries (>70%) compared to non-DVT patients (p=0.003).
  • Pulmonary lesions <50% were more common in patients without DVT (p=0.0001).
  • The Gamma variant was associated with increased prevalence of DVT and mortality (p=0.0001).

Conclusions:

  • Deep vein thrombosis is an aggravating factor for mortality in SARS-CoV-2 patients.
  • The Gamma variant exacerbates both thrombotic events and mortality in COVID-19.
Abstract

Keywords:
Covid-19deep vein thrombosismortalitypulmonary thrombosis

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