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In situ hybridization (ISH) is a technique used to detect and localize specific DNA or RNA molecules in cells, tissue, or tissue sections using a labeled probe. The technique was first used in 1969 for the investigation of nucleic acids. It is currently an essential tool in scientific research and clinical settings, especially for diagnostic purposes.
Types of probes and labels
A probe is a complementary strand of DNA or RNA that binds to corresponding nucleotide sequences in a cell. Many...
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Progress in Probe-Based Sensing Techniques for In Vivo Diagnosis.

Cheng Zhou1,2, Zecai Lin1,2, Shaoping Huang1,3

  • 1Institute of Medical Robotics, Shanghai Jiao Tong University, Shanghai 200240, China.

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Summary

Probe-based sensors enhance robotic surgery for precise diagnosis and treatment. This review covers recent Chinese advancements in in vivo physical and biochemical sensing technologies for minimally invasive procedures.

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biochemical sensingendoluminal interventionin vivo diagnosisminimally invasive surgeryphysical sensing

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Area of Science:

  • Medical Robotics
  • Biomedical Engineering
  • Sensing Technologies

Background:

  • Robotic surgery offers precise, minimally invasive endoluminal diagnosis and treatment.
  • Miniaturized probe-based sensors integrated with medical robots improve procedural convenience and data acquisition.
  • In vivo sensing technologies provide crucial physiological information during interventions.

Purpose of the Study:

  • To review recent advancements in probe-based sensing techniques for in vivo physical and biochemical sensing.
  • To highlight developments in China's research landscape for these technologies.
  • To cover key sensing modalities including force, temperature, imaging, and chemical/biomarker detection.

Main Methods:

  • Literature review focusing on Chinese research in probe-based in vivo sensing.
  • Categorization of sensing techniques based on measured parameters (physical, biochemical).
  • Analysis of sensor integration with medical robotic systems.

Main Results:

  • Significant progress in developing various in vivo probe-based sensors for physical and biochemical sensing.
  • Key areas of advancement include in vivo force sensing, temperature sensing, and advanced imaging techniques (OCT, photoacoustic, ultrasound).
  • Emerging applications in chemical and biomarker sensing for enhanced diagnostic capabilities.

Conclusions:

  • Probe-based sensing technologies are crucial for advancing robotic endoluminal interventions.
  • Continued innovation in China is driving the development of sophisticated in vivo sensing solutions.
  • These integrated technologies promise safer, more precise, and informative minimally invasive procedures.