Synthesis and Characterization of TiO₂ Thick Films for Glucose Sensing

In this paper, we present the results of a non-enzymatic electrochemical glucose biosensor based on TiO₂. An anatase working electrode was synthesized using the spin coating technique with the polymeric precursor method and dispersed TiO₂ nanoparticles. Through scanning electron microscopy, it was observed that the electrode presented an irregular surface with clusters of nanoparticles. Electrochemical characterization indicated that the response was directly related to the morphology of the electrode. In the presence of glucose, the electrode exhibited adsorption behavior toward the molecules, enabling their recognition. The electrode was tested by employing PBS (phosphate buffer solutions) with varying pH values (from 4 to 9), demonstrating its electrochemical stability, even in the presence of glucose. Amperometric characterization was used to determine that the working region appeared from 0.2 mM to 2 mM, with a sensitivity of 4.46 μAcm^-2mM^-1 in PBS pH 7. The obtained results suggest that TiO₂-based electrodes could be used for the detection of glucose concentration in sweat (0.277-1 mM) and saliva (0.23-1.77 mM).