Related Experiment Video
Updated: Aug 22, 2025
04:19
The Establishment of a Murine Mandibular Molar Extraction Socket Healing Model
Published on: January 13, 2023
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Solid PRF Serves as Basis for Guided Open Wound Healing of the Ridge after Tooth Extraction by Accelerating the Wound
Shahram Ghanaati1,2, Joanna Śmieszek-Wilczewska2, Sarah Al-Maawi1
1FORM-Lab, Department for Oral, Cranio-Maxillofacial and Facial Plastic Surgery, Medical Center of the Goethe University Frankfurt, Goethe University, 60590 Frankfurt am Main, Germany.
Bioengineering (Basel, Switzerland)
|November 10, 2022
Summary
Platelet-rich fibrin (PRF) significantly accelerates ridge sealing and reduces soft tissue contraction after tooth extraction. This promotes predictable healing for future dental implant procedures.
Area of Science:
- Regenerative Dentistry
- Oral Surgery
- Biomaterials Science
Background:
- Limited systematic evaluations exist on Platelet-Rich Fibrin (PRF) in ridge sealing.
- This study addresses the potential of solid PRF in soft tissue socket healing post-extraction.
Purpose of the Study:
- To investigate the efficacy of systematically applied solid PRF on soft tissue socket healing.
- To evaluate ridge sealing and soft tissue contraction in molar and premolar extraction sockets over 90 days.
Main Methods:
- A randomized, controlled clinical trial was conducted.
- Qualitative and quantitative image analysis was used to assess healing.
- Patient pain perception was monitored.
Main Results:
- PRF significantly accelerated ridge sealing within 7-10 days for both tooth types.
- PRF treatment resulted in visibly less soft tissue contraction at 90 days.
- No statistical significance in pain perception, though PRF group reported less pain.
Conclusions:
- PRF promotes the secondary wound healing cascade and acts as a natural growth factor delivery system.
- PRF facilitates predictable guided open wound healing with reduced soft tissue contraction.
- This approach is crucial for successful subsequent dental implantation and oral rehabilitation.
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