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Pharmacodynamics of Dracorhodin Perchlorate and Its Inflammation-Targeting Emulsion Gel for Wound Healing
Xiaojie Wang1,2, Xue Guo3, Ran Yu2
1School of Chemistry and Environmental Engineering, Wuhan Institute of Technology, Wuhan 430205, China.
Abstract:
The mechanism of dracorhodin perchlorate for the repair of rat skin wounds was investigated. In order to screen a more favorable drug delivery system for wound repair, the therapeutic effect of dracorhodin perchlorate inflammation-targeted emulsion gel was compared with that of non-targeted emulsion gel on rat wounds. Compared with non-targeted emulsion gels, inflammation-targeted emulsion gels had a better transdermal penetration and lower potentials (-51.6 mV and -17.1 mV, respectively). The recovery of the wound from the dracorhodin perchlorate inflammation targeted emulsion gel group was better than that of the dracorhodin perchlorate inflammation non-targeted emulsion gel group and the positive drug group. Compared with the no-target emulsion gel group, the bFGF expression on day 7 and the EGF expression on day 14 in the targeted emulsion group showed 45.5% and 49.9% improvement, respectively. Pathological tissue slices showed that the epidermis, dermis, and basal layer inflammatory cells in the inflammation-targeted emulsion gel group and non-targeted emulsion gel group were significantly reduced, the granulation tissue proliferation was obvious, and the inflammation-targeted emulsion gel group was more effective. The results proved that dracorhodin perchlorate had a repairing effect on rat skin wounds, and its mechanism might be related to the promotion of the expression of EGF and bFGF in tissues.
Insights
Dracorhodin perchlorate effectively repairs rat skin wounds, particularly when delivered via inflammation-targeted emulsion gels. This targeted approach enhances transdermal penetration and promotes healing by increasing growth factor expression.
Area of Science:
- Biomaterials Science
- Wound Healing Research
- Pharmacology
Background:
- Dracorhodin perchlorate demonstrates potential for skin wound repair.
- Optimizing drug delivery systems is crucial for enhancing therapeutic efficacy.
- Inflammation-targeted delivery systems offer improved therapeutic outcomes.
Purpose of the Study:
- To investigate the wound repair mechanism of dracorhodin perchlorate.
- To compare the therapeutic effects of inflammation-targeted versus non-targeted emulsion gels for dracorhodin perchlorate delivery.
- To evaluate the impact of targeted delivery on transdermal penetration and wound healing indicators.
Main Methods:
- Comparative study of dracorhodin perchlorate in inflammation-targeted and non-targeted emulsion gels on rat skin wounds.
- Assessment of transdermal penetration and zeta potential.
- Measurement of epidermal growth factor (EGF) and basic fibroblast growth factor (bFGF) expression.
- Histopathological analysis of wound tissue.
Main Results:
- Inflammation-targeted emulsion gels exhibited superior transdermal penetration and lower zeta potential compared to non-targeted gels.
- The targeted dracorhodin perchlorate group showed significantly better wound recovery than non-targeted and positive drug control groups.
- Enhanced expression of bFGF (day 7) and EGF (day 14) was observed in the targeted group.
- Histopathology revealed reduced inflammation and improved granulation tissue formation in both emulsion gel groups, with greater efficacy in the targeted group.
Conclusions:
- Dracorhodin perchlorate possesses significant wound-repairing properties for rat skin.
- Inflammation-targeted emulsion gel delivery enhances dracorhodin perchlorate's therapeutic effect on wound healing.
- The mechanism of action may involve promoting EGF and bFGF expression, indicating a role in tissue regeneration.
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