Thermosensitive In Situ Gels for Joint Disorders: Pharmaceutical Considerations in Intra-Articular Delivery
Marina Koland1, Anoop Narayanan Vadakkepushpakath1, Anish John1
1Department of Pharmaceutics, NGSM Institute of Pharmaceutical Sciences (NGSMIPS), Nitte (Deemed to be University), Mangalore 575018, India.
Gels (Basel, Switzerland)
|November 10, 2022
Summary
Thermosensitive hydrogels offer improved drug retention for joint diseases like osteoarthritis, providing sustained release and reducing inflammation. Further research addresses formulation challenges for enhanced therapeutic effects.
Area of Science:
- Biomaterials Science
- Polymer Chemistry
- Rheology
Background:
- Conventional intra-articular drug delivery for joint diseases has limited efficacy due to short drug retention times.
- Thermosensitive hydrogels offer a promising solution by forming depots for sustained drug release near body temperature.
Purpose of the Study:
- To review the application of thermosensitive gels for intra-articular therapeutics in joint disorders.
- To summarize recent advancements, including nanoparticle incorporation, in thermosensitive hydrogel drug delivery.
Main Methods:
- Focus on thermosensitive hydrogels as stimuli-responsive gelling systems for intra-articular drug delivery.
- Discussion of temperature-sensitive polymers (e.g., block copolymers, poloxamers) and their role in gelation.
- Exploration of hydrogel composition, drug release mechanisms, and formulation challenges.
Main Results:
- Thermosensitive hydrogels provide prolonged drug retention and sustained release, improving therapeutic outcomes.
- Incorporation of nanoparticles offers potential for enhanced drug delivery and treatment efficacy.
- Challenges in formulation, storage, stability, and biocompatibility of thermosensitive hydrogels are identified.
Conclusions:
- Thermosensitive hydrogels represent a significant advancement in intra-articular drug delivery for joint diseases.
- Addressing formulation and stability challenges is crucial for optimizing their clinical application.
- Future developments may focus on improving biocompatibility and controlled drug release kinetics.
Related Concept Videos
01:22Drug Delivery: Miscellaneous Routes
438
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection, and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
438
01:28Factors Influencing Drug Absorption: Pharmaceutical Parameters
179
Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
179