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Related Experiment Video

Updated: Aug 22, 2025

Isolation of Salivary Epithelial Cells from Human Salivary Glands for In Vitro Growth as Salispheres or Monolayers

Isolation of Salivary Epithelial Cells from Human Salivary Glands for In Vitro Growth as Salispheres or Monolayers

Published on: July 15, 2019

Hydrogels for Salivary Gland Tissue Engineering.

Sangeeth Pillai¹, Jose G Munguia-Lopez¹, Simon D Tran¹

¹McGill Craniofacial Tissue Engineering and Stem Cells Laboratory, Faculty of Dental Medicine and Oral Health Sciences, McGill University, 3640 Rue University, Montreal, QC H3A 0C7, Canada.

Gels (Basel, Switzerland)

|November 10, 2022

Summary

Hydrogels are key for salivary gland (SG) tissue engineering, supporting cell growth and function in vitro and ex vivo. Future research should focus on hydrogel properties that enhance mechanotransduction for better SG models.

Keywords:

ECM hydrogels mechanotransduction salivary glands signaling pathways

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Isolation of Salivary Epithelial Cells from Human Salivary Glands for In Vitro Growth as Salispheres or Monolayers

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Published on: July 15, 2019

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Synthesis of Thermogelling PolyN-isopropylacrylamide-graft-chondroitin Sulfate Composites with Alginate Microparticles for Tissue Engineering

Published on: October 26, 2016

Area of Science:

Biomaterials Science
Tissue Engineering
Regenerative Medicine

Background:

Mimicking the complex, branched structure of salivary glands (SGs) is difficult.
In vitro and ex vivo models have advanced SG structure and function recapitulation.
Hydrogels mimic the extracellular matrix, supporting cell and tissue integrity.

Purpose of the Study:

To review ideal hydrogel biomaterials for salivary gland engineering.
To discuss advances in natural and synthetic hydrogels for SG applications.
To highlight the importance of mechanotransduction and signaling cues in hydrogel design.

Main Methods:

Review of natural and synthetic hydrogels in SG tissue engineering.
Discussion of hydrogel properties supporting cell proliferation, reorganization, and polarization.
Analysis of signaling pathways relevant to hydrogel-based SG models.

Main Results:

Hydrogel-based culture of SG cells shows success in expansion, artificial gland formation, and transplantation.
Both natural and synthetic hydrogels support SG epithelial cell behavior.
Improvements in hydrogel properties are crucial for sophisticated SG models.

Conclusions:

Hydrogels are versatile platforms for salivary gland tissue engineering.
Optimizing hydrogel properties, including mechanotransduction support, is essential for future advancements.
Continued research into hydrogel-based SG models holds promise for restoring SG function.