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Related Concept Videos

Tumor Immunotherapy01:27

Tumor Immunotherapy

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
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Related Experiment Video

Updated: Aug 22, 2025

Intravital Microscopy of Tumor-associated Vasculature Using Advanced Dorsal Skinfold Window Chambers on Transgenic Fluorescent Mice
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Decrease in Tumor Interstitial Pressure for Enhanced Drug Intratumoral Delivery and Synergistic Tumor Therapy.

Yihan Fu1, Fei Ye1, Xuwu Zhang1

  • 1State Key Laboratory of Metastable Materials Science and Technology, Nano-biotechnology Key Lab of Hebei Province, Applying Chemistry Key Lab of Hebei Province, Yanshan University, Qinhuangdao066004, P. R. China.

ACS Nano
|November 10, 2022
PubMed
Summary

This study introduces a novel nanomotor that reduces tumor interstitial pressure (TIP) by splitting water, enhancing drug delivery and inhibiting cancer growth. This innovative approach tackles a key challenge in effective tumor treatment.

Keywords:
Z-scheme photocatalytic drugnanodrug intratumor deliverytransition metal-sulfide compoundstumor interstitial pressuretumor therapy

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Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Nanotechnology

Background:

  • High tumor interstitial pressure (TIP) impedes drug delivery and promotes tumor progression.
  • Current treatments face limitations due to poor drug penetration into tumor centers.

Purpose of the Study:

  • To develop a nanomotor capable of reducing TIP and enhancing anti-cancer efficacy.
  • To investigate a novel Z-scheme photocatalytic system for combined therapeutic effects.

Main Methods:

  • Fabrication of AWS@M nanomotors via in situ growth of Ag2S on WS2.
  • Utilizing photocatalytic water splitting to reduce TIP and generate oxygen in tumor interstitial fluid.
  • Employing generated oxygen to produce reactive oxygen species (ROS) and induce hyperthermia.

Main Results:

  • AWS@M nanomotors effectively reduced TIP in cervical and pancreatic cancer models (40.2% and 36.1% degradation).
  • Significant inhibition of tumor growth observed (95.83% and 87.61% inhibition ratios).
  • Enhanced intratumoral drug delivery and elimination of deep tumor cells demonstrated.

Conclusions:

  • The nanomotor successfully addresses the challenge of high TIP, improving drug delivery.
  • Combined ROS generation and hyperthermia offer a potent strategy for tumor eradication.
  • This work presents a generalizable approach for advanced cancer therapy.