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A 96 Well Microtiter Plate-based Method for Monitoring Formation and Antifungal Susceptibility Testing of Candida albicans Biofilms

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Overview of Analytical Methods for Evaluating Tinidazole.

Jean Carlos Pereira Sousa¹, Ana Carolina Kogawa¹

¹Quality Control Laboratory, School of Pharmacy, Federal University of Goias, 74605-170, Goiânia - GO, Brazil.

Journal of AOAC International

|November 10, 2022

Summary

Analytical methods for tinidazole (TIN) quality control are reviewed, highlighting limitations of current techniques and the need for greener approaches. The literature indicates a need for developing new analytical methods for TIN that align with green analytical chemistry principles.

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Area of Science:

Pharmaceutical Analysis
Green Chemistry
Quality Control

Background:

Tinidazole (TIN) possesses broad-spectrum antimicrobial and antiprotozoal activities, necessitating robust analytical methods for quality assurance.
Current quality control (QC) methods for TIN, such as non-aqueous titration, present environmental and safety concerns due to solvent usage and material scale.

Approach:

This review systematically analyzes existing physicochemical and microbiological methods for TIN evaluation in pharmaceutical matrices.
It assesses these methods against routine QC requirements and the principles of green analytical chemistry (GAC).

Key Points:

Ultraviolet (UV) spectroscopy (41%) and High-Performance Liquid Chromatography (HPLC) (28%) are the most prevalent physicochemical methods for TIN analysis.
Agar diffusion and turbidimetric methods are equally common for microbiological assessments.
TIN tablets constitute the primary matrix studied, with methanol being the most frequently used solvent.

Conclusions:

The current analytical landscape for TIN reveals significant opportunities for developing methods that adhere to GAC principles.
Optimizing time, resources, and materials while minimizing waste and hazardous reagents is crucial for future TIN analysis.
This review provides a comprehensive overview of TIN analytical methods, emphasizing their relevance to industrial QC and GAC.