Related Experiment Video
Updated: Jun 17, 2026
Highly Efficient Gene Disruption of Murine and Human Hematopoietic Progenitor Cells by CRISPR/Cas9
Published on: April 10, 2018
Applying CRISPR-Cas9 screens to dissect hematological malignancies
Deepak Narayanan Iyer1,2, Aaron D Schimmer3,4, Hong Chang1,2
1Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.
Clustered regularly interspaced short palindromic repeats (CRISPR)-CRISPR-associated protein 9 (Cas9) screening advances cancer genomics research. These tools are crucial for understanding blood cancer biology and developing precision medicine strategies.
Area of Science:
- Genomics
- Molecular Biology
- Cancer Research
Background:
- Limited understanding of genes driving cancer development and progression hinders effective disease management.
- Functional genomic tools have progressively illuminated cancer's molecular underpinnings.
- Recent technological advancements are crucial for deciphering complex cancer-associated physiological processes.
Conclusions:
- CRISPR-Cas9 technology is revolutionizing cancer genomics and translational research.
- Its application in hematological malignancies offers promising avenues for next-generation precision medicine.
- Continued advancements in CRISPR-Cas9 screening will be vital for improving blood cancer patient outcomes.
More Related Videos
08:14Lentiviral CRISPR/Cas9-Mediated Genome Editing for the Study of Hematopoietic Cells in Disease Models
Published on: October 3, 2019
07:01Evaluation of Abnormal Growth-related Genes of Hematopoietic Stem and Progenitor Cells by Combining CRISPR/Cas9 Technology with Cell Counting
Published on: May 2, 2025
