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Published on: May 8, 2013
Genetic Diversity among Methicillin-Resistant Staphylococcus aureus in Malaysia (2002-2020)
Hassanain Al-Talib1, Syahirah Samsudin2, Ariza Adnan1
1Department of Medical Microbiology and Parasitology, Faculty of Medicine, Universiti Teknologi MARA (UiTM), Sungai Buloh 47000, Malaysia.
Abstract:
1.
Background:
Methicillin-resistant Staphylococcus aureus (MRSA) is a common organism seen in both healthcare-associated and community-associated infections worldwide and in Malaysia over the past two decades. The aim of this review is to provide a firsthand documentation of all MRSA strains prevalent in the Malaysian population from 2002 to present and briefly describe the changing patterns. 2.
Methods:
Electronic and manual intensive literature searches were conducted between 2002 and 2020, addressing issues directly related to patients and published in the English language were selected. 3.
Results:
The literature search retrieved a total of 2217 articles and abstracts of 27 articles. The search yielded a total of 24 articles on genotyping of MRSA in Malaysia. The study found that MRSA strains were mostly genetically related and resulted in the predominant MRSA clones that caused active infections. Thirty-six different sequence types (ST) were recorded. The highest rates of STs detected were ST239 (52.6%), ST1 (47.4%), and ST22 (42.1%). The majority of studies showed that both SCCmec types III and IV were the most common SCCm type in Malaysia, followed by SCCmec type V (57.9%). 4.
Conclusions:
Both Brazilian (ST 239 IIIA) and Hungarian (ST 239-III) MRSA strains were detected in Malaysia. PFGE remains the best method for comparing MRSA strains. However, whole-genome sequencing has a promising chance to replace PFGE in the future.
Insights
Methicillin-resistant Staphylococcus aureus (MRSA) strains in Malaysia are genetically related, with ST239, ST1, and ST22 being predominant. Brazilian and Hungarian MRSA strains were identified, highlighting the need for advanced genotyping methods.
Area of Science:
- Microbiology
- Infectious Diseases
- Genetics
Background:
- Methicillin-resistant Staphylococcus aureus (MRSA) is a significant pathogen causing infections globally and in Malaysia.
- MRSA has been prevalent in Malaysia for the past two decades, necessitating an understanding of its evolving patterns.
Purpose of the Study:
- To document prevalent MRSA strains in Malaysia from 2002 to the present.
- To describe the changing patterns of MRSA infections in the Malaysian population.
Main Methods:
- Conducted intensive electronic and manual literature searches from 2002 to 2020.
- Selected English-language publications focusing on MRSA in Malaysian patients.
- Analyzed 24 articles on MRSA genotyping in Malaysia.
Main Results:
- Identified 36 different sequence types (STs) of MRSA.
- Predominant STs included ST239 (52.6%), ST1 (47.4%), and ST22 (42.1%).
- SCCmec types III and IV were most common, followed by SCCmec type V (57.9%).
Conclusions:
- Detected both Brazilian (ST 239 IIIA) and Hungarian (ST 239-III) MRSA strains in Malaysia.
- Pulsed-field gel electrophoresis (PFGE) is currently the preferred method for MRSA strain comparison.
- Whole-genome sequencing shows potential to supersede PFGE for future MRSA strain analysis.
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