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Updated: Aug 22, 2025

Measuring G-protein-coupled Receptor Signaling via Radio-labeled GTP Binding
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The interaction, mechanism and function of GPR158-RGS7 cross-talk

Shradha V Darira1, Laurie P Sutton1

  • 1Department of Biological Sciences, University of Maryland Baltimore County, Baltimore, MD, United States.

Progress in Molecular Biology and Translational Science
|November 10, 2022
PubMed
Summary

The G protein-coupled receptor 158 (GPR158) interacts with regulator of G protein signaling 7 (RGS7), influencing stress-induced depression. Their complex structure and function are key to understanding stress modulation in the brain.

Keywords:
Crystal structureDepressionG protein signalingGPCRGPR158Mood regulationRGS7Signaling complexStresscAMP

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