The Impact of Organ Procurement Injury on Transplant Organ Availability

Elizabeth Taber-Hight1, Anil Paramesh2, Nikole Neidlinger3

  • 1Indiana University Division of Nephrology, Department of Medicine, Indianapolis, Indiana.

Transplantation Proceedings
|November 10, 2022
PubMed

Insights

Procurement organ injuries during deceased donation are rare but lead to significant allograft loss. The right kidney is most frequently injured, impacting transplantable organs.

Area of Science:

  • Transplantation Surgery
  • Organ Procurement
  • Medical Device Injury

Background:

  • Organ transplant waiting lists are long due to low organ supply.
  • Initiatives aim to increase organ allograft supply, focusing on deceased donors.
  • Minimizing organ injury during procurement is crucial.

Purpose of the Study:

  • To analyze the incidence and degree of organ procurement injuries.
  • To identify factors associated with organ procurement injuries.
  • To assess the impact of procurement injuries on allograft availability.

Main Methods:

  • Data collected from 29 US organ procurement organizations (Nov 2017 - Jan 2020).
  • Analysis of total injury rates and Level 3 injuries (allograft loss).
  • Comparison of injury rates between donation after brain death and donation after circulatory death.

Main Results:

  • Total injury rates: 6% (brain death) to 8.4% (circulatory death).
  • Level 3 injury rates: 1.1% (brain death) to 1.6% (circulatory death).
  • The right kidney was the most commonly injured organ leading to allograft loss. Injuries were more frequent in donors without prior abdominal surgery and from attending surgeons.

Conclusions:

  • Deceased donor procurement organ injuries, while rare, result in substantial loss of transplantable organs annually.
  • Understanding injury patterns and associated factors can help improve organ preservation.
  • Reducing procurement injuries is vital to maximize organ utilization and shorten transplant waiting times.

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