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The Impact of Organ Procurement Injury on Transplant Organ Availability
Elizabeth Taber-Hight1, Anil Paramesh2, Nikole Neidlinger3
1Indiana University Division of Nephrology, Department of Medicine, Indianapolis, Indiana.
Abstract:
Patients on the transplant waiting list continue to have a significant wait time as organ supply remains low. Many initiatives have been undertaken in the last few years to attempt to increase the organ allograft supply. As organ procurement organizations have attempted to increase their procurement of organs from deceased donors, emphasis has been placed on avoidance of injury to organs during procurement. To analyze the success of this attention, data were collected from 29 of 57 organ procurement organizations in the United States. Data collection was from November 2017 to January 2020. Total injury rate ranged from 6% (donation after brain death) to 8.4% (donation after circulatory death). Level 3 injuries, those resulting in loss of the allograft, ranged from 1.1% in donation after brain death to 1.6% in donation after circulatory death. The most likely injured organ resulting in loss of viability (level 3 injury) during procurement was the right kidney. We noted that among donors with procurement injuries, a higher number had no previous abdominal surgery and there were more injuries noted from attending surgeons (compared to trainees). Deceased donor procurement organ injuries, though rare, lead to substantial loss of transplantable organs every year. Given that the United Network for Organ Sharing has recorded >10,000 deceased donors yearly for the past few years, such injuries can result in hundreds of transplantable organs lost. In this article we detailed the incidence and degree of injury and some variables that may be associated with these injuries.
Insights
Procurement organ injuries during deceased donation are rare but lead to significant allograft loss. The right kidney is most frequently injured, impacting transplantable organs.
Area of Science:
- Transplantation Surgery
- Organ Procurement
- Medical Device Injury
Background:
- Organ transplant waiting lists are long due to low organ supply.
- Initiatives aim to increase organ allograft supply, focusing on deceased donors.
- Minimizing organ injury during procurement is crucial.
Purpose of the Study:
- To analyze the incidence and degree of organ procurement injuries.
- To identify factors associated with organ procurement injuries.
- To assess the impact of procurement injuries on allograft availability.
Main Methods:
- Data collected from 29 US organ procurement organizations (Nov 2017 - Jan 2020).
- Analysis of total injury rates and Level 3 injuries (allograft loss).
- Comparison of injury rates between donation after brain death and donation after circulatory death.
Main Results:
- Total injury rates: 6% (brain death) to 8.4% (circulatory death).
- Level 3 injury rates: 1.1% (brain death) to 1.6% (circulatory death).
- The right kidney was the most commonly injured organ leading to allograft loss. Injuries were more frequent in donors without prior abdominal surgery and from attending surgeons.
Conclusions:
- Deceased donor procurement organ injuries, while rare, result in substantial loss of transplantable organs annually.
- Understanding injury patterns and associated factors can help improve organ preservation.
- Reducing procurement injuries is vital to maximize organ utilization and shorten transplant waiting times.
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