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Autoimmune diseases and cardiovascular risk
Joel M Gelfand1, Sonia Wang2, Michael S Garshick3
1Department of Dermatology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA; Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA.
Trends in Molecular Medicine
|November 10, 2022
Summary
Autoimmune diseases, affecting millions, are linked to cardiovascular disease (CVD). Chronic inflammation from conditions like rheumatoid arthritis and psoriasis significantly increases CVD risk, necessitating new mitigation strategies.
Area of Science:
- Immunology
- Cardiology
- Public Health
Background:
- Autoimmune diseases affect 4-8% of the global population, with over 80 distinct types identified.
- Chronic inflammation is a known contributor to the development of atherosclerotic cardiovascular disease (CVD).
Purpose of the Study:
- To investigate the association between autoimmune diseases and cardiovascular disease (CVD).
- To identify specific autoimmune conditions that act as risk enhancers for CVD.
Main Methods:
- Analysis of data from a study published in The Lancet.
- Identification of autoimmune diseases associated with a composite of cardiovascular disease.
Main Results:
- A composite of cardiovascular disease was associated with 19 different autoimmune diseases.
- Psoriasis and rheumatoid arthritis were specifically identified as enhancers of CVD risk.
- Inflammation was confirmed as a key mechanism promoting atherosclerotic CVD.
Conclusions:
- There is a significant link between numerous autoimmune diseases and cardiovascular disease.
- Targeting chronic inflammation is crucial for reducing CVD morbidity and mortality in patients with autoimmune conditions.
- Further research is needed to develop effective strategies for managing CVD risk in this population.
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