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Updated: Aug 22, 2025

Evaluation of Left Ventricular Structure and Function using 3D Echocardiography

Evaluation of Left Ventricular Structure and Function using 3D Echocardiography

Published on: October 28, 2020

Analysing functional implications of differences in left ventricular morphology using statistical shape modelling.

Froso Sophocleous¹, Lucy Standen¹, Gemina Doolub²

¹Bristol Medical School, Faculty of Life Sciences, Bristol Heart Institute, Bristol Royal Infirmary, University of Bristol, Upper Maudlin Street, Bristol, BS2 8HW, UK.

Scientific Reports

|November 10, 2022

Summary

This summary is machine-generated.

Left ventricular (LV) shape changes in congenital heart disease, specifically coarctation of the aorta (CoA) and bicuspid aortic valve (BAV), are linked to impaired cardiac function. Increased LV sphericity correlates with reduced strain, regardless of aortic arch or valve issues.

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Last Updated: Aug 22, 2025

Evaluation of Left Ventricular Structure and Function using 3D Echocardiography

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Published on: October 28, 2020

Morphological and Functional Assessment of the Right Ventricle Using 3D Echocardiography

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Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction

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Published on: February 13, 2021

Area of Science:

Cardiology
Medical Imaging
Biomedical Engineering

Background:

Left ventricular (LV) morphology's functional impact in congenital heart disease (CHD) is under-researched.
Aortic coarctation (CoA) and bicuspid aortic valve (BAV) are common CHDs often presenting together, affecting cardiac hemodynamics.

Purpose of the Study:

To investigate the association between LV shape, LV function, and thoracic aortic morphology in patients with CoA and/or BAV.
To explore the functional implications of altered LV morphology using advanced shape analysis.

Main Methods:

Utilized a statistical shape modeling framework on 3D cardiac magnetic resonance (CMR) data.
Analyzed LV shapes in isolated CoA, CoA+BAV, isolated BAV, and healthy control groups.
Correlated LV shape parameters (sphericity, conicity) with LV strain and aortic arch architecture.

Main Results:

The LV in CoA patients was found to be shorter and more spherical.
Increased LV sphericity significantly correlated with reduced global and apical radial and circumferential strain.
LV morphology differences were noted between CoA and BAV groups, with sphericity linked to reduced strain independent of aortic arch or valve disease.

Conclusions:

LV morphological alterations, particularly increased sphericity, are present in CoA and associated with impaired LV function (reduced strain).
These findings highlight the functional significance of LV shape in CHD and suggest it as a potential imaging biomarker.
Shape analysis offers valuable insights into cardiac mechanics beyond traditional functional parameters in CHD patients.