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Related Concept Videos

Mutations01:35

Mutations

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Mutations are changes in the sequence of DNA. These changes can occur spontaneously or they can be induced by exposure to environmental factors. Mutations can be characterized in a number of different ways: whether and how they alter the amino acid sequence of the protein, whether they occur over a small or large area of DNA, and whether they occur in somatic cells or germline cells.
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All radioactive nuclides emit high-energy particles or electromagnetic waves. When this radiation encounters living cells, it can cause heating, break chemical bonds, or ionize molecules. The most serious biological damage results when these radioactive emissions fragment or ionize molecules. For example, α and β particles emitted from nuclear decay reactions possess much higher energies than ordinary chemical bond energies. When these particles strike and penetrate matter, they...
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Related Experiment Video

Updated: Aug 22, 2025

Application of Laser Micro-irradiation for Examination of Single and Double Strand Break Repair in Mammalian Cells
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Radiation-Induced Rescue Effect: Insights from Microbeam Experiments.

Kwan Ngok Yu1

  • 1Department of Physics, City University of Hong Kong, Hong Kong, China.

Biology
|November 11, 2022
PubMed
Summary
This summary is machine-generated.

The Radiation-Induced Rescue Effect (RIRE) shows targeted cells can be protected from radiation damage by signals from non-irradiated cells. Microbeam experiments offer unique insights into this radiobiology phenomenon.

Keywords:
microbeamnon-targeted effectradiation biology

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Area of Science:

  • Radiobiology
  • Cellular signaling
  • Radiation effects

Background:

  • The Radiation-Induced Rescue Effect (RIRE) is a non-targeted radiobiological phenomenon.
  • RIRE involves mitigation of radiation effects in targeted cells via signals from co-cultured non-irradiated cells or conditioned medium.

Purpose of the Study:

  • To review the Radiation-Induced Rescue Effect (RIRE).
  • To explore insights from microbeam experiments on RIRE.
  • To discuss RIRE's relationship with other radiobiological effects like RIBE, RIFSE, and FLASH.

Main Methods:

  • Literature review of RIRE.
  • Analysis of previous microbeam irradiation studies on RIRE.
  • Survey of proposed mechanisms for RIRE observations.

Main Results:

  • RIRE demonstrates a protective feedback mechanism in radiobiology.
  • Microbeam irradiations provide unique capabilities for studying RIRE.
  • RIRE is linked to other emerging radiobiological concepts.

Conclusions:

  • RIRE is a significant radiobiological effect with potential therapeutic implications.
  • Microbeam technology is crucial for advancing RIRE research.
  • Future research should leverage microbeam features to explore RIRE mechanisms and applications.