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Myeloperoxidase as a Potential Biomarker of Acute-Myocardial-Infarction-Induced Depression and Suppression of the

Andreas Baranyi1, Dietmar Enko2, Andreas Meinitzer2

  • 1Division of Psychiatry and Psychotherapeutic Medicine, Medical University of Graz, 8036 Graz, Austria.

Antioxidants (Basel, Switzerland)
|November 11, 2022
PubMed

Insights

Myeloperoxidase (MPO) levels decrease in patients experiencing depression after acute myocardial infarction (AMI). Lower baseline MPO predicts future depression, suggesting MPO as a biomarker for AMI-induced depression and immune suppression.

Area of Science:

  • Immunology
  • Cardiology
  • Psychiatry

Background:

  • Myeloperoxidase (MPO) indicates neutrophil and innate immune function.
  • Acute myocardial infarction (AMI) can lead to depression, potentially involving immune system suppression.
  • Decreased MPO serum levels may indicate this immune suppression in AMI patients.

Purpose of the Study:

  • To assess MPO serum concentration changes immediately and 6 months post-AMI.
  • To determine if MPO levels predict AMI-induced depression and immune suppression.

Main Methods:

  • Prospective study of 109 AMI patients.
  • Assessed depression using Hamilton Depression Scale (HAMD-17) at admission and 6 months.
  • Measured serum MPO levels at the same time points.

Main Results:

  • Depressive patients had significantly lower MPO levels immediately and 6 months post-AMI.
  • Baseline MPO levels were a significant predictor of depression 6 months after AMI (p=0.027).

Conclusions:

  • MPO is a potential biomarker for AMI-induced depression.
  • Lower MPO levels suggest a depression-associated suppression of the innate immune system in AMI patients.
Keywords:
acute myocardial infarctiondepressioninnate immune systemmyeloperoxidase

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