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Cancer Stem Cells and Tumor Maintenance02:40

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Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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Tumor Immunotherapy01:27

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
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Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
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Soluble CD26: From Suggested Biomarker for Cancer Diagnosis to Plausible Marker for Dynamic Monitoring of Immunotherapy.

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CD26-Related Serum Biomarkers: sCD26 Protein, DPP4 Activity, and Anti-CD26 Isotype Levels in a Colorectal Cancer-Screening Context.

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Correction: Adeluola et al. Chemoprevention of 4-NQO-Induced Oral Cancer by the Combination of Resveratrol and EGCG: In Vivo, In Silico and In Vitro Studies. <i>Cancers</i> 2026, <i>18</i>, 1098.

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Isolation of Group 2 Innate Lymphoid Cells from Mouse Nasal Mucosa to Detect the Expression of CD226
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CD26 and Cancer.

Oscar J Cordero1,2,3

  • 1Department of Biochemistry and Molecular Biology, CIBUS Building, University of Santiago de Compostela, 15782 Santiago de Compostela, Spain.

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Summary
This summary is machine-generated.

This Special Issue explores the complex behavior of dipeptidyl peptidase 4 (DPP4), a key enzyme in metabolic regulation. New research reveals insights into DPP4

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Area of Science:

  • Biochemistry and enzyme kinetics.
  • Metabolic regulation and signaling pathways.

Background:

  • Dipeptidyl peptidase 4 (DPP4) is a crucial enzyme involved in glucose homeostasis.
  • Dysregulation of DPP4 activity is linked to metabolic disorders like type 2 diabetes.

Discussion:

  • This issue compiles cutting-edge research on DPP4's multifaceted roles.
  • Investigating DPP4's interactions and functions provides a deeper understanding of metabolic control.

Key Insights:

  • Novel findings on DPP4's substrate specificity and enzymatic mechanisms.
  • Exploration of DPP4's non-canonical functions beyond incretin degradation.

Outlook:

  • Future research directions for DPP4 inhibitors and therapeutic strategies.
  • Potential for DPP4 modulation in treating a wider range of metabolic and inflammatory diseases.