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Related Concept Videos

Fungal Phylum Microsporidia01:28

Fungal Phylum Microsporidia

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Microsporidia are a group of obligate intracellular fungi that were initially classified as protists but were later reclassified based on phylogenetic, molecular, and structural evidence linking them to the Chytridiomycota. These unicellular, non-motile organisms are highly specialized parasites that infect a wide range of animal hosts, including humans. They have evolved extensive genomic and metabolic reductions, making them highly dependent on their hosts for survival.Morphology and Genomic...
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Factors Affecting the Risk of Infection01:26

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The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
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As the name suggests, non-LTR retrotransposons lack the long terminal repeats characteristic of the LTR retrotransposons. Additionally, both LTR and non-LTR retrotransposons use distinct mechanisms of mobilization. Non-LTR retrotransposons are further divided into two classes - Long interspersed nuclear elements (LINEs) and short interspersed nuclear elements (SINEs), both of which occur abundantly in most mammals, including humans. Some of the active non-LTR retrotransposons in humans are L1...
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Latent Microsporidia Infection Prevalence as a Risk Factor in Colon Cancer Patients.

Fernando Redondo1, Carolina Hurtado-Marcos1, Fernando Izquierdo1

  • 1Facultad de Farmacia, Universidad San Pablo-CEU, CEU Universities, Urbanización Montepríncipe, 28660 Boadilla del Monte, Spain.

Cancers
|November 11, 2022
PubMed
Summary

Microsporidia infections were found in 41.3% of colon cancer patients, but not in healthy controls. This suggests a potential link between microsporidia and colon cancer development.

Keywords:
ELISAEncephalitozoon sp.Enterocytozoon bieneusiIFATcolon cancermicrosporidia

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Area of Science:

  • * Parasitology and Oncology
  • * Microbial pathogenesis and cancer etiology

Background:

  • * Microsporidia are opportunistic intracellular parasites causing severe illness in immunocompromised individuals.
  • * Microsporidial infections can interfere with apoptosis and cell cycle regulation via p53 and Caspase 3 inhibition, processes critical in epithelial cell malignancy.
  • * The role of microsporidia in the etiopathogenesis of colon cancer (CC) remains largely unexplored.

Purpose of the Study:

  • * To investigate the prevalence of microsporidia in intestinal tissues of colon cancer patients.
  • * To assess the seroprevalence of anti-Encephalitozoon antibodies in colon cancer patients.
  • * To explore the potential association between microsporidia and the development of colon cancer.

Main Methods:

  • * Real-time PCR and immunofluorescence antibody testing were used to detect microsporidia in intestinal tissues.
  • * Enzyme-linked immunosorbent assay (ELISA) was employed to analyze serum for anti-Encephalitozoon antibodies (IgG and IgE).
  • * The study included 87 colon cancer patients and 25 healthy controls.

Main Results:

  • * Microsporidia were detected in the tissues of 36 (41.3%) colon cancer patients, with no detection in controls (p < 0.0001).
  • * Elevated levels of IgG and IgE anti-Encephalitozoon antibodies were observed in colon cancer patients, indicating prior or ongoing exposure.
  • * A statistically significant association was found between microsporidia presence and colon cancer.

Conclusions:

  • * The high prevalence of microsporidia in colon cancer tissues and elevated antibody levels suggest a significant association.
  • * Microsporidia may play a role in the etiopathogenesis of colon cancer.
  • * Further research is warranted to elucidate the precise mechanisms linking microsporidia to colon cancer development.