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Glioblastoma Relapse Post-Resection Model for Therapeutic Hydrogel Investigations

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Resilience in Lower Grade Glioma Patients.

Ellen Fröhlich¹, Claudia Sassenrath², Minou Nadji-Ohl³

¹Department of Neurosurgery, University of Ulm, 89312 Günzburg, Germany.

|November 11, 2022

Summary

Resilience is crucial for lower grade glioma (LGG) patients. Over a third of LGG patients exhibit low resilience, significantly impacted by poor functional status and stigmatization.

Keywords:

ISBI RS-13 diffuse astrocytoma distress internalized stigmatization lower grade glioma occupation oligodendroglioma pain resilience

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Area of Science:

Neuro-oncology
Psychological Oncology

Background:

Resilience is vital for cancer patient well-being.
Understanding resilience in lower grade glioma (LGG) patients is essential.

Purpose of the Study:

To explore resilience levels in adult LGG patients.
To identify factors influencing resilience in this population.

Main Methods:

Cross-sectional study of 74 adult LGG patients from the LoG-Glio registry.
Data collected via phone interviews using validated scales (RS-13, distress thermometer, MoCA-Blind, ISBI, ECOG, PPQ) and clinical parameters.

Main Results:

38% of LGG patients demonstrated low resilience.
Resilience correlated significantly with distress, cognitive function (MoCA), performance status (ECOG), stigmatization, and pain.
Multivariate analysis identified elevated ECOG performance status and stigmatization as key negative predictors of resilience.

Conclusions:

Low resilience is prevalent in over one-third of LGG patients.
Poor functional status (ECOG) is a significant risk factor for low resilience.
The substantial impact of stigmatization on resilience is a novel finding requiring clinical attention in glioma patients.