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Targeted Therapies in Advanced and Metastatic Urothelial Carcinoma

Andrew B Katims1, Peter A Reisz1, Lucas Nogueira1

  • 1Urology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

Cancers
|November 11, 2022
PubMed

Insights

Targeted therapies offer new hope for advanced urothelial carcinoma patients. Advances in molecular characterization are driving the development of novel treatments beyond traditional chemotherapy and immunotherapy.

Area of Science:

  • Oncology
  • Urothelial Carcinoma Research
  • Molecular Targeted Therapy

Background:

  • Advanced urothelial carcinoma treatment relies on platinum-based chemotherapy and immunotherapy.
  • Current standard treatments yield median overall survival under one year, highlighting a critical need for improved therapies.
  • Next-generation sequencing enables detailed molecular profiling of urothelial tumors.

Purpose of the Study:

  • To review the current landscape of targeted therapies for urothelial carcinoma.
  • To discuss the development and potential of novel molecularly targeted agents.
  • To explore the future integration of these therapies into earlier stages of urothelial carcinoma treatment.

Main Methods:

  • Comprehensive review of existing literature on targeted therapies in urothelial carcinoma.
  • Analysis of molecular characterization data from next-generation sequencing studies.
  • Evaluation of clinical trial outcomes for targeted agents in advanced disease.

Main Results:

  • Identification of key molecular pathways (FGFR, Nectin-4, Trop-2, HER2) driving urothelial carcinogenesis.
  • Development of targeted therapies, including FGFR inhibitors and agents targeting Nectin-4, Trop-2, and HER2.
  • Demonstrated efficacy of these targeted therapies in the second-line setting for advanced urothelial carcinoma.

Conclusions:

  • Targeted therapies represent a significant advancement in urothelial carcinoma treatment.
  • These novel agents are poised to shift the treatment paradigm towards earlier disease stages.
  • Continued research into molecular drivers and targeted agents is crucial for improving patient survival.
Keywords:
antibody-drug conjugatesantineoplastic therapyimmunotherapymetastatic urothelial carcinomamolecular targeted therapymonoclonal antibodiesnext-generation sequencingtumor biomarkers

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