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Autotaxin in Breast Cancer: Role, Epigenetic Regulation and Clinical Implications

Andrianna Drosouni1, Maria Panagopoulou1,2, Vassilis Aidinis3

  • 1Laboratory of Pharmacology, Medical School, Democritus University of Thrace, 68100 Alexandroupolis, Greece.

Cancers
|November 11, 2022
PubMed

Insights

Autotaxin (ATX) and lysophosphatidic acid (LPA) signaling drives breast cancer progression. Targeting ENPP2 expression and epigenetic modifications offers potential for novel diagnostics and therapeutics.

Area of Science:

  • Biochemistry and Molecular Biology
  • Oncology
  • Cancer Research

Background:

  • Autotaxin (ATX), encoded by ENPP2, produces lysophosphatidic acid (LPA), a lipid mediator implicated in biological processes.
  • Aberrant ATX-LPA signaling is linked to cancer progression, metastasis, and inflammation, particularly in breast cancer.
  • ENPP2 has emerged as a potential therapeutic target and biomarker in breast cancer management.

Purpose of the Study:

  • To review recent findings on aberrant ATX-LPA signaling in breast cancer.
  • To discuss the significance of ENPP2 expression and epigenetic modifications in breast cancer.
  • To provide insights with translational value for clinical applications.

Main Methods:

  • Literature review of recent studies on ATX-LPA signaling in breast cancer.
  • Analysis of research on ENPP2 gene expression and its epigenetic regulation.
  • Synthesis of findings related to the translational potential of ATX-LPA pathway in breast cancer.

Main Results:

  • The ATX-LPA pathway plays a critical role in breast cancer development and progression.
  • Aberrant ENPP2 expression and epigenetic alterations are observed in breast cancer.
  • ENPP2 methylation presents a promising avenue for liquid biopsy applications.

Conclusions:

  • The ATX-LPA pathway is a key player in breast cancer pathogenesis.
  • ENPP2 expression and epigenetic status are relevant for breast cancer biomarkers and therapeutics.
  • Targeting ENPP2 and its pathway holds translational promise for breast cancer treatment and diagnosis.
Keywords:
ATX-LPA signalingENPP2autotaxinbreast cancerepigeneticsexpressionlysophosphatidic acidmethylation

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